Sharif Digital Repository

Today, knowledge is the most important resource in software development. The success of software development relies on the exchange of knowledge between software developers working in different agile teams. The purpose of this research is to determine the size of agile teams according to knowledge sharing factors. Knowledge sharing factors between work teams have been extracted by searching articles; Then, all these factors, which are classified into five main categories: individual, organizational, technological, cultural, and geographical, were investigated and separated according to the working conditions in Iran, and finally, the important factors were identified by the evaluation of... 

To design a drug delivery system, the drug must be encapsulated within a carrier matrix. One of the main challenges in this field is encapsulating high drug doses while achieving a linear release profile at the target site to maintain drug concentration for optimal therapeutic effects. Consequently, many research groups have focused on refining fabrication techniques to maximize loading efficiency and optimize drug release profiles from delivery systems. A potential approach to addressing this issue is the direct fabrication of a controlled-release system from the active pharmaceutical ingredient (API) itself, eliminating the need for a carrier matrix. Studies have demonstrated that such... 

Osteoarthritis is a common musculoskeletal disorder and the most prevalent form of arthritis. To date, no comprehensive cure has been reported for osteoarthritis, and its clinical management remains challenging. The primary therapeutic goals in the early stages of osteoarthritis are to increase joint mobility and control disease progression by continuously releasing drugs and molecules modulating inflammatory responses and reducing pain. Smart drug delivery platforms are one of the strategies to overcome the challenges of injectable and oral medications. Additionally, drug carrier particles can have different therapeutic targets based on their size and shape. Different therapeutic... 

Since oil prices continue to increase, energy conservation remains the prime industrial concern. Existing processes in power plants and oil refineries are not energy efficient as they should be therefore new projects can be defined to increase the energy efficiency without incurring any cost. The most appropriate utility for the processes should be explored to reduce emissions, increase the plant capacities and improve product qualities and energy efficiencies by one coherent strategic plan for the overall site which can be achieved by a full understanding of pinch technology and awareness of the available tools for applying it in practical way. Since the distillation unit of crude oil... 

Macrophages play a crucial role in the healing process of chronic wounds in diabetic patients. These cells polarize from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype, guiding the initial inflammation toward tissue repair and regeneration. In diabetic patients, physiological disturbances impair this polarization, resulting in persistent, chronic, and inflamed wounds. Glucocorticoid anti-inflammatory drugs are commonly used but have serious side effects, necessitating targeted delivery systems. This study aims to design and optimize self-assembled complex coacervate drug delivery system composed of gelatin and sodium alginate (GA/SA CCA) that can selectively uptake by... 

Graphene quantum dots (GQDs) as a sort of carbon-based nanomaterials are applied in a multitude of exciting areas. They are effective fluorescent probe for many potential biological and medical applications. In comparison to conventional organic fluorescent probes (organic dyes), GQDs have substantial advantages, such as photostability, excellent solubility, low cytotoxicity and biocompatibility.
In this thesis, green fluorescent GQDs have been prepared via solvothermal method from graphite powder.Various analysis methods were utilized to characterization of the product. So, several experiments on GQDs in solution and in solid substrate at room temperature have been performed. The... 

Due to unusual response of structures of buildings with irregularity in their architecture to dynamic excitations, to have a comprehensive knowledge of their behavior during earthquakes is of utmost importance. Building irregularities are in general divided into two major categories, namely Irregularity in Plane and Irregularity in Elevation, and one of the forms of the latter is where there is a split in the levels of the building. In this work, through a series of case studies, the effects of P- phenomenon on the behavior of steel split-level building structures were studied. 5, 10 and 15 story buildings with 5 and 6 bays, and level splitting of 30, 60, 90, 120 and 150 cm were studied. All... 

Mesoscopic hydrodynamic equations are solved employing a VOF based method to investigate the equilibrium shape of nanodroplets positioned over various topographic geometries of the supporting substrate for three-dimensional systems. By taking into account liquid-liquid and liquid-solid interactions a complex distribution for inter-molecular forces over the substrates (the disjoining pressure) is observed. In this research we show that motion of nanodroplets not only caused by contact angle difference in drplets two sides, but also depend on disjoining pressure parameters.Geometries with increasing complexities, from wedges to three dimensional edges and wedges, were explored with the main... 

Observations made after previous earthquakes have shown the crucial role of irregularities in initiating damage in buildings with irregularity, either in Plan or in Elevation. Since in existing Building Codes, there is no provision for the distribution of the Equivalent Static Loads for such buildings, designers have no option but to resort to Dynamic Analysis. In this work, the seismic behaviour of a group of two-dimensional steel building structures with irregularity in elevation, namely Split-Level buildings, was studied. The studied structures consist of a series of 5- and 15-storey frames having two parts with splitting distance of 150 cm. Both, moment-resisting and braced frames were... 

With the road transportation vehicles being widely used, concerns have been increased regarding their unwanted effects. Air pollution, climate change, and oil supply security are among these effects. Many alternative fuels and propulsion systems have been proposed to be used instead of conventional ICE vehicles in recent decades. This project intends to conduct a Techno-Economic comparison between different vehicle powertrains so as to select the suitable choice to substitute conventional ICE vehicles. The vehicle options are ICE vehicles using both gasoline and CNG as fuels, Hybrid Electric Vehicles (HEVs), Plug-in Hybrid Electric Vehicles (PHEVs), and Electric Vehicles (EVs). The amount of... 

Base plates as the connecting components of steel structures to their foundations, have a crucial role in the behavior of these structures. In order to limit the thickness of base plates hence their cost within reasonable values, various types of attachments (stiffeners) are normally added to them. In this project 6 different configurations, Models, for the base plate and its attachments were considered and studied through finite element analysis. Each Model was studied under the combination of biaxial moments and a range of compressive loads including 0, 0.05 P/Py, 0.10 P/Py and 0.15 P/Py, where Py is the plastic load of the column. The moment-rotation curves of all models under various... 

Reducing air pollutant emissions from vehicles is a difficult and time consuming procedure which needs utilizing of modern emission control equipment and setting strict regulations for car factories and drivers as well. How efficient these policies are and proposing operative solutions for air quality improvement depend on developing a sustainable model which is used in vehicle emission predictions and their share in total emissions. Emission factors are not constant values as they can be affected by various operational and ambient parameters. Development of Emission inventories calls for a huge number of measurements using different vehicles in diverse conditions. Thus, recognition of... 

The city of Tehran is dealing with air pollution problems for years. Providing a solution for this problem requires information about different pollutants emission sources. In this subjects, emission factors and emission models are essential tools for decision makers. Among different mobile emission sources in Tehran, motorcycles are of high importance. In this project, for the first time in Iran, exhaust gas pollutants emission of 66 motorcycles with different ages and engine displacement volumes were measured according to Euro-3 standard certification procedure. Measurement results showed that none of the tested motorcycles passed the Euro-3 certification limit on CO emission. Calculations... 

Homogeneous Charge Compression Ignition (HCCI) engines are the new generation of internal combustion engines which have diesel-like thermal efficiency, while they have low nitrogen oxide and soot emission. One of the major problems of HCCI engines is combustion timing control due to its dependence on reactivity of the charge and chemical kinetics. Moreover, limiting operation range between knock and misfiring is the other drawback of using these kind of engines. In the present work, partially homogeneous HCCI combustion in a single cylinder diesel engine is modeled using Computational Fluid Dynamics (CFD) coupled with chemical kinetics. Simulation includes the engine cycle from exhaust valve... 

Today air pollution has become one of the major urban management concerns. Air pollution could have dangerous effects on human health in short time or long time in many situations. Numerical modelling is one of the most applicable among different ways for predicting pollutant concentration like field measurement, physical model in wind tunnel, and simulation. Modelling of pollutant dispersion is a way for estimating concentration and aggregation of the pollutant near the surface and with different distances from pollution source. In different dispersion models, one of simplest is the Gaussian model. In this approach it is supposed that emission plume obeys from Gaussian distribution and is... 

Due to the important role of base plates, both in transferring forces from the structure to the foundation, and also in transferring vibrations from soil to the structure, it is necessary to have sufficient knowledge on their behaviour and performance under monotonic and cyclic loading regimes. In fact, the behaviour of the supports of any structure cannot be identified without identifying the behaviour of its base plates. Numerous configurations with/without various types of attachments have been proposed and used for base plates. In this work, altogether six commonly-used types of base plates were studied and their behaviour under monotonic and cyclic loadings was obtained using commercial... 

Past earthquakes show that irregular structures have been more vulnerable than their regular counterparts. One of the common types of irregular buildings in urban areas is split-level ones. On the other hand, beam-to-column connections in steel structures are mostly of "semi-rigid" type. In this work, effects of different levels of rigidity of connections, 100%, 75%, 50% and 25%, on the behavior of a number of two-dimensional split-level steel structures, with 1.5 m difference in levels of floors, 2, 3, 5 and 6 bays, and 5, 10 and 15 stories, were studied. All frames were analyzed “with” and “without” considering the P-∆ phenomenon, with two methods, ‘equivalent static load,’ and ‘modal... 

In recent years, the idea of Homogenous charge compression ignition (HCCI) engines has been in the center of attention as a new generation of internal combustion engines. Intense decrease in pollutant emission rate like NOx, low fuel consumption and high thermal efficiency are the main reasons of why these engines are in center of attention, however, some drawbacks, which the main one combustion control which happens in limited operation range between knock and misfiring has limited the use of these engines. Hence approaches like adding synthesis gas, using exhaust gas recirculation, controling effective comperession ratio by using variable valve timing, changing the input conditions... 

Tehran, with approximately 750 km2 of land area, a population of more than 8 million people with about 4 million active on-road vehicles, is dealing with serious air pollution problems. To model the environmental phenomenon precisely, this study aims to develop on-road air pollutant emission factor matrices based on existing traffic in Tehran routes and to run air quality modelling within Tehran geographic boundaries. We developed emission factor matrices using SMOKES-MOVES emission modeling system. To do so, we calculated on-road emission factors from actual traffic-related data and run MOVES emission model. And use use them for different pollutants considered in air quality models. Then,...