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vasei--hamed
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Semi-supervised Breast Cancer Subtype Clustering Using Microarray Datasets
, M.Sc. Thesis Sharif University of Technology ; Motahhari, Abolfazl (Supervisor)
Abstract
Gene expression microarrays can be used for precision medicine and targeted therapies. The data generated by microarrays are high-dimensional causing statistical inference of any parameter a daunting task. In this thesis, it is shown that regardless of high-dimensional datasets produced by microarrays, the inference can be robust in the sense that random selection of features results in the same conclusion as far as the number of selected features are chosen appropriately. Stratifying patients with breast cancer based on their gene expression levels shows that patient subtypes are almost independent of the feature selection strategy. Moreover, using less noisy datasets coming from RNAseq...
Stable dye-sensitized solar cells based on a gel electrolyte with ethyl cellulose as the gelator
, Article Applied Physics A: Materials Science and Processing ; Volume 120, Issue 3 , September , 2015 , Pages 869-874 ; 09478396 (ISSN) ; Tajabadi, F ; Jabbari, A ; Taghavinia, N ; Sharif University of Technology
Springer Verlag
2015
Abstract
A simple gelating process is developed for the conventional acetonitrile-based electrolyte of dye solar cells, based on ethyl cellulose as the gelator. The electrolyte becomes quasi-solid-state upon addition of an ethanolic solution of ethyl cellulose to the conventional acetonitrile-based liquid electrolyte. The photovoltaic conversion efficiency with the new gel electrolyte is only slightly lower than with the liquid electrolyte, e.g., 6.5 % for liquid electrolyte versus 5.9 % for gel electrolyte with 5.8 wt% added ethyl cellulose. Electrolyte gelation has small effect on the ionic diffusion coefficient of iodide, and the devices are remarkably stable for at least 550 h under irradiation...
Two-machine flow shop scheduling to minimize the sum of maximum earliness and tardiness
, Article International Journal of Production Economics ; Volume 122, Issue 2 , 2009 , Pages 763-773 ; 09255273 (ISSN) ; Mirzaee, M ; Vasei, M ; Modarres, M ; Azaron, A ; Sharif University of Technology
2009
Abstract
This paper presents optimal scheduling in a two-machine flow shop, in which the objective function is to minimize the sum of maximum earliness and tardiness (n/2/P/ETmax). Since this problem tries to minimize earliness and tardiness, the results can be useful for different production systems such as just in time (JIT). This objective function has already been considered for n jobs and m machines, but the proposed algorithms are not efficient to solve large scale problems. In this paper, neighborhood conditions are developed and the dominant set for any optimal solution is determined. The branch-and-bound (B&B) method is used to solve the problem and the proper upper and lower bounds are also...
Enhanced chondrogenic differentiation of human bone marrow mesenchymal stem cells on PCL/PLGA electrospun with different alignments and compositions
, Article International Journal of Polymeric Materials and Polymeric Biomaterials ; Volume 67, Issue 1 , 2018 , Pages 50-60 ; 00914037 (ISSN) ; Mahmoudifard, M ; Soleimani, M ; Bakhshandeh, B ; Vasei, M ; Faghihi, S ; Sharif University of Technology
Taylor and Francis Inc
2018
Abstract
The simultaneous effect of electrospun scaffold alignment and polymer composition on chondrogenic differentiation of human bone marrow mesenchymal stem cells (hBMMSC) is investigated. Aligned and randomly oriented polycaprolactone/poly(lactic-co-glycolic acid) (PLGA) hybrid electrospun scaffolds with two different ratios are fabricated by electrospinning. It is found that aligned nanofibrous scaffolds support higher chondrogenic differentiation of hBMMSCs compared to random ones. The aligned scaffolds show a higher expression level of chondrogenic markers such as type II collagen and aggrecan. It is concluded that the aligned nanofibrous scaffold with higher PLGA ratio could significantly...
An efficient tabu search algorithm for the single row facility location problem [electronic resource]
, Article European Journal Of Operational Research ; Vol. 205, No. 1, pp. 98-105 ; Eshghi, Kourosh ; Sharif University of Technology
Abstract
The general goal of the facility layout problem is to arrange a given number of facilities to minimize the total cost associated with the known or projected interactions between them. One of the special classes of the facility layout problem is the Single Row Facility Layout Problem (SRFLP), which consists of finding an optimal linear placement of rectangular facilities with varying dimensions on a straight line. This paper first presents and proves a theorem to find the optimal solution of a special case of SRFLP. The results obtained by this theorem prove to be very useful in reducing the computational efforts when a new algorithm based on tabu search for the SRFLP is proposed in this...
Sensitivity analysis of matching pennies game [electronic resource]
, Article Mathematical and Computer Modelling ; Volume 51, Issues 5–6, March 2010, Pages 722–735 ; Eshghi, Kourosh ; Sharif University of Technology
Abstract
In this paper, we have discussed the results of sensitivity analysis in a payoff matrix of the Matching Pennies game. After representing the game as a LP model, the sensitivity analysis of the elements of the payoff matrix is presented. The game value and the optimal strategies for different values of parameters are determined and compared
Parametric study and computation of seismic performance factors of braced shear panels
, Article Scientia Iranica ; Volume 23, Issue 2 , 2016 , Pages 460-474 ; 10263098 (ISSN) ; Mofid, M ; Sharif University of Technology
Sharif University of Technology
2016
Abstract
By locating a steel shear panel on the intersection point of the X-braces, concentrically or eccentrically braced shear panel (CBFSP or EBFSP) is formed. In this paper, to perform parametric study, 1-story CBFSP and EBFSP models with span length greater or less than height are considered. Using linear static analyses, the effects of size and location of the shear panel on the lateral stiffness of the frame with respect to the moment resisting frame with the same member sections are investigated. Next, for 1- And 3-story models, maximum displacement, along with base shear, and the ratio between the dissipated energy and input energy are examined under 4 ground motion records. Behavior of the...
Assessment of Seismic Retrofit Policies for Buildings
, M.Sc. Thesis Sharif University of Technology ; Kashani, Hamed (Supervisor)
Abstract
Occurrence of natural disasters such as earthquake could seriously damage most buildings especially those with insufficient resistance located in urban worn-out textures. In order to reduce unpleasant consequences of an earthquake, appropriate policies need to be considered to persuade the beneficiaries to follow retrofitting standards in the process of planning, designing, and construction of buildings. These policies shall be implemented through institutions in arbitrary or obligatory forms, by encouragement or penalty mechanisms. In order to consider these policies, first of all we need to identify the beneficiaries and their particulars. By studying and considering subjects discussed in...
Optimal-Robust Control of Drug Delivery in Cancer Chemotherapy
, M.Sc. Thesis Sharif University of Technology ; Moradi, Hamed (Supervisor)
Abstract
Chemotherapy is a proven and effective systematic approach to treat various types of cancers. Despite its advantages, chemotherapy would kill healthy as well as cancer cells. To overcome this problem, different controlling strategies are implemented. This study aims to provide a medicine drug delivery schedule for chemotherapy (by designing a proper controlling system) based on the verifiable mathematical models. First, the dynamic model is analysed and stability points are reviewed. The selected model has five state variables and two inputs. In this study, the focus is on dynamic model analysis and obtaining an effective and appropriate treatment pattern by designing a proper controller. To...
Real Options Analysis Framework for the Optimal Timing of Network Infrastructure Systems Retrofits
, M.Sc. Thesis Sharif University of Technology ; Kashani, Hamed (Supervisor)
Abstract
Natural disasters can damage the infrastructure of society. Damages to the infrastructure components of society can disrupt their service delivery. Disruption in providing services to society's infrastructure can disrupt social and economic activities and impose various significant costs on society. The cost of repairing the damaged infrastructure and reducing the income of households are among the economic damages of accidents. The decline in the quality of life, as well as the death and injury of people due to the breakdown of the infrastructure or the disruption in their services, are among the social damages caused by accidents. In the same way, natural disasters are considered a...
Analysis of Seismic Vulnerability Reduction Policies of Residential Buildings Using a Multi-agent Evolutionary Game Model Based on Prospect Theory
, M.Sc. Thesis Sharif University of Technology ; Kashani, Hamed (Supervisor)
Abstract
Due to the vulnerability of urban fabric and residential buildings to earthquakes and considering its destructive social and economic effects on society, the need to adopt appropriate policies to prevent and reduce vulnerability, has been increasingly considered by policy makers. Despite the laws, regulations, incentives and penalties that policymakers have envisioned to prevent unprincipled and unsafe construction, evidence shows that a significant number of new buildings being built in the country are not earthquake resistant and there are many violations in design, implementation and supervision that is done by the stakeholders. To solve this problem, research has been done on the...
Development of a Multi-functional Soil Column for Studying Bioremediation and Multiphase Flow
, M.Sc. Thesis Sharif University of Technology ; Sadeghi, Hamed (Supervisor)
Abstract
Soil and water pollution is one of the most common types of pollution in terrestrial and aquatic ecosystems. The development of mines and the oil and petrochemical industry on one hand and the non-compliance with environmental requirements on the other hand have caused large amounts of hydrocarbon pollutants and heavy metals to enter the environment in recent decades. Petroleum materials and heavy metals leak into the surrounding environment during drilling and extraction in oil sites and mines or during land and sea transportation, despite the measures taken to control their pollution. The conducted studies show that human industrial activities are the only cause of environmental pollution...
Developing Novel Algorithms to Simultaneous Power Regulation and Load Mitigation of Modern Variable Speed Wind Turbines
, Ph.D. Dissertation Sharif University of Technology ; Moradi, Hamed (Supervisor)
Abstract
The power control of horizontal axis wind turbines can affect significantly the vibration loads and fatigue life of the tower and the blades. In this thesis, we are going to consider both the power control and vibration load mitigation of the tower fore-aft vibration. For this purpose, at first, we developed a fully coupled model of the NREL 5MW turbine. This model considers the full aeroelastic behavior of the blades and tower and is validated by experiment results, comparing the time history data with the FAST (Fatigue, Aerodynamics, Structures, and Turbulence ) code which is developed by NREL (National Renewable Energy Lab in the United States). In the next, to estimate EWV, a novel...
Laboratory Investigation of the Effects of Sodium Chloride Concentration on Soil Water Retention Curve and Volumetric behavior Using an Unsaturated Automatic Oedometer
, M.Sc. Thesis Sharif University of Technology ; Sadeghi, Hamed (Supervisor)
Abstract
Laboratory studies to investigate the effects of different saline concentrations (such as sodium chloride or calcium chloride) on the soil water retention behavior of clayey soils and their volumetric changes have received much attention recently. However, many previous studies have investigated these effects in only one path of the SWRC (wetting or drying path) and the effects of saline concentration on hydraulic hysteresis have not been considered. In addition, researchers have frequently studied these effects on SWRC on clay samples, and little research has been done on collapsible soils. Therefore, the most important purpose of this study is to investigate the effects of increasing...
Robust and Nonlinear Control of the Boiler-Turbine Unit Performance in a Coal Fired Ultra-Supercritical Once Through Boiler Power Plant in Order to Optimize the Uncertain Problem
, M.Sc. Thesis Sharif University of Technology ; Moradi, Hamed (Supervisor)
Abstract
Nowadays electricity power has a key role in developing various aspects of the world. The great importance of fossil fuel power plants come from their large contribution in electricity power generation. Among the different fossil fuel power generation technologies, supercritical power plants have great advantages. They are an advanced power generation technology with high plant efficiency, high coal utilization and low emission. Their complexity and existing many unavoidable uncertainty sources in their dynamic such as changes of ambient temperature, climate condition and wear of components make their control challenging. To overcome mentioned problems and achieving a good performance, a...
Numerical Modeling of Stability and Transport of Soluble Contaminants in Tailings Dams under Coupled Hydro-Chemical Processes (A Case Study of Sarcheshmeh Tailings Dam)
, M.Sc. Thesis Sharif University of Technology ; Sadeghi, Hamed (Supervisor)
Abstract
The instability and contamination leakage through tailings dams is one of the major problems of them. These dams are usually constructed through self-consolidation with minimum compaction effort, so special attention must be given to the stability of these structures. In addition, tailings dams contain considerable amounts of metals and chemically soluble contaminants resulting from mining processes in their reservoirs, making them more likely to leak contamination from the dam's foundation and body, causing pollution downstream. The infiltration of various chemical contaminants into the soil may alter its hydraulic and resistance properties. Laboratory studies have shown that pore solution...
Modelling and Electromechanical Control of Variable Speed wind Turbine in Order to Gain Maximum Wind Power
, M.Sc. Thesis Sharif University of Technology ; Moradi, Hamed (Supervisor)
Abstract
In this research, the main purpose of the controller design is in the second region of operation of a wind turbine, which involves absorbing the maximum energy from the wind. WindPACT 1.5MW turbine has been investigated and the power coefficient of this turbine has been obtained using WT-PERF and FAST softwares. Simulations show that the results of both methods are well matched. Then, using ANFIS, a method for estimating the wind speed is derived from the data obtained by FAST. Inputs to the ANFIS system are the turbine aerodynamic power, rotor speed and blade pitch angle while the output of ANFIS system is the estimated wind speed. The maximum power coefficient of the wind turbine occurs...
Design of a Robust Active Controller to Suppress the Undesirable Vibration of Power Transmission Lines by Using the Intermediate Actuators and Optimization of Their Locations
, M.Sc. Thesis Sharif University of Technology ; Moradi, Hamed (Supervisor)
Abstract
Power transmission lines, which are responsible for the distribution and transmission of electrical energy from the power plant to the consumer areas, due to their characteristics such as long length and flexibility with low structural damping, face environmental irritations, especially the galloping phenomenon, causing many damages annually. In this study, it has been attempted to reduce the vibrations of power transmission lines by designing a robust active control and by using intermediate actuators in such a way that the failures of these lines can be prevented. For this purpose, linear modeling of the system and designing the controller using the pole replacement method have been done....
Nonlinear Vibration Analysis of Non-Uniform Beam in two Lateral Directions by Multiple Scales Method: Application in Wind Turbine
, M.Sc. Thesis Sharif University of Technology ; Moradi, Hamed (Supervisor)
Abstract
Environmental issues and energy crisis have led the world attention to the renewable energies; especially wind power, since they have low cost and high reliability. One of the most challenging areas of studying for wind power is to increase the capacity of wind turbines. As a result, over the years, wind turbines have got progressively larger. Vibration is one of the problems that reduces the life and efficiency of wind turbines; and the growing size of the blades has worsen this problem due to the importance of nonlinear effects in large scale wind turbines. Researchers have been constantly working on this issue in order to make the wind turbines more efficient. In this research, a...
Machine Learning Models for Estimating House Prices
, M.Sc. Thesis Sharif University of Technology ; Kashani, Hamed (Supervisor)
Abstract
Optimal use of available resources for construction projects depends on proper decision-making on how to spend resources. Optimization of resource consumption should be done taking into account project revenue. In this regard, investors need a suitable mechanism to predict the selling price of the construction project and the resulting profit. Therefore, investors and stakeholders need a suitable model with the help of which they can make decisions such as choosing materials to guarantee the desired profit from the sale. This research will provide a framework for constructing models for estimating the price of residential units by considering some features of the building and some economic...