Sharif Digital Repository

In the present work, the multivariate kinetic complexation of a new synthesized ligand, 1-(2″-hydroxyl cyclohexyl)-3′-[aminopropyl]-4-[3′-aminopropyl]piperazine (Pizda) and Cu2+ in 50% ethanol-water solution is investigated using the UV-vis stopped-flow technique and state-of-the-art multi-wavelength numerical analysis. Model-based least squares fitting analysis or hard modeling is a specific part of chemometrics which is based on mathematical relationships for describing the measurements. Some recent developments include the incorporation of the effects of non-ideal experimental conditions into the fitting algorithm so it can substantially simplify experimental procedures. In this study no... 

Traffic is a major contributor to emissions in many large cities with severe air pollution. Experience in London, Milan, and Stockholm shows that charging for the use of roads can be effective in reducing emissions, as well as congestion. This study examines the use of predictive cordon tolls based on weather forecasts to reduce ambient air pollution and congestion. Travelers choose their destinations inside or outside the cordon, and whether to drive or take public transport. Passenger vehicles are divided into three classes according to their emission characteristics, and higher tolls are imposed on more polluting vehicles. The Box model of emission dispersion is used to predict air... 

High morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made coronavirus disease 2019 (COVID-19) the leading challenge for health experts all over the world. Currently, there is no specific treatment for COVID-19; however, thanks to worldwide intense attempts, novel vaccines such as mRNA-1273 (Moderna TX, Inc.) and BNT162b2 (Biontech/Pfizer) were developed very fast and FDA approved them for emergency use. Nanomedicine-based drug delivery can be an advanced therapeutic strategy to deal with clinical complications of COVID-19. Given the fact that SARS-CoV-2 typically affects the respiratory tract, application of inhalable nanoparticles (NPs)... 

One problem that has always been a challenge for geotechnical engineers is construction on problematic and soft soils. Traditional methods of lime and cement stabilisation can be used to treat soils with these properties. The main drawback of lime addition to the clayey soils is a significant loss in ductility of lime-treated soils. Using ductile materials such as geogrids in lime-treated soils is one of the most effective ways to increase the soil ductility. Therefore, the effect of geogrids and lime on unconfined compressive strength (UCS), failure strain (ɛf), secant modulus (Es), deformability indexes (ID), resilient modulus (Mr), bulk modulus (K), and shear modulus (G) of the treated... 

One problem that has always been a challenge for geotechnical engineers is construction on problematic and soft soils. Traditional methods of lime and cement stabilisation can be used to treat soils with these properties. The main drawback of lime addition to the clayey soils is a significant loss in ductility of lime-treated soils. Using ductile materials such as geogrids in lime-treated soils is one of the most effective ways to increase the soil ductility. Therefore, the effect of geogrids and lime on unconfined compressive strength (UCS), failure strain (ɛf), secant modulus (Es), deformability indexes (ID), resilient modulus (Mr), bulk modulus (K), and shear modulus (G) of the treated... 

Rotational ambiguity is a central but not well investigated problem in all soft-modelling analyses of multivariate data. A novel method which is based on Resolving Factor Analysis (RFA) is proposed. Completely general and exhaustive results are presented for the two-component case. In particular the effects of noise and global analysis of series of measurements are investigated. Copyright © 2007 John Wiley & Sons, Ltd  

Breast cancer incidence has increased in recent decades. In the present study, an optimum formulation of chitosan (CS)-adorned niosome-based nanocarriers for co-delivery of doxorubicin (DOX) and vincristine (VIN) was developed for the treatment of breast cancer to reduce drug doses and overcome multidrug resistance. The three-level Box-Behnken method was utilized to optimize the particles in terms of size, polydispersity index (PDI), entrapment efficacy (EE (%)), and percent of drug release (%). The release rate of two drugs from CS-adorned nanoparticles (DOX+VIN/Nio/CS) in acidic and physiological pH is less than uncoated niosome (DOX+VIN/Nio). In addition, acidic pH increases the release... 

Introduction: The application of doxorubicin (DOX) in cancer therapy has been limited due to its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the capacity for DOX delivery while promoting its cytotoxicity in cancer. Areas covered: The favorable characteristics of GO nanocomposites, preparation method, and application in cancer therapy are described. Then, DOX resistance in cancer, GO-mediated photothermal therapy, and DOX delivery for cancer suppression are described. Preparation of stimuli-responsive GO nanocomposites, surface functionalization, hybrid nanoparticles, and theranostic applications are emphasized in DOX chemotherapy. Expert opinion: GO... 

Learning a foreign language encompasses a process of trial and error that can lead to the progression of the learner's interlanguage, meaning that the learners make use of their language knowledge that receives feedback and brings about progress through diagnosis of the problems and being corrected by the teacher. Therefore, there exists a need to analyze the underlying reasons causing the students to remain taciturn with a low willingness to communicate (WTC) during a language class. There has been much work done investigating the role of the learner's stable personal characteristics (traits) along with their situational changes at a specific time (states) that influence the student's... 

Accurate system identification (SI) is essential for flight controller design of unmanned aerial vehicles and microaerial vehicles (MAVs). SI can be performed either in frequency or time domain using flight test data. As flight testing is often costly and may even lead to catastrophic events before some flight stability analysis is at hand, a low-cost 5 degree-of-freedom free motion platform (FMP) is designed and used for initial identification of MAVs via wind tunnel testing. A typical MAV is constructed as a test case and equipped with inertial sensors for testing and validation purposes. The proposed FMP allows for both rotational as well as translational motions that in turn provide for... 

Using 3-D scanned data to analyze and extract pore network plays a vital role in investigation of porous media's characteristics. In this paper, a new simple method is developed to detect pores and throats for analyzing the connectivity and permeability of the network. This automated method utilizes some of the common and well-known image processing functions which are widely accessible by researchers and this has led to an easy algorithm implementation. In this method, after polishing and quality control of images, using city-block distance function and watershed segmentation algorithm, pores and throats are detected and 3-D network is produced. This method can also be applied on 2-D images... 

In this paper, we try to recognize and distinguish different groups of arrhythmia using novel features which have been obtained from the heart rate's phase space in recent years. For this purpose, we used Triangular Phase Space Mapping (TPSM) and Parabolic Phase Space Mapping (PPSM). For recognition, we used three groups of 15 subjects using the Physionet database (Arrhythmia, Congestive Heart Failure (CHF), and Atrial Fibrillation (AF)) with Normal Sinus Rhythm (NSR). The obtained features discriminate arrhythmia from NSR by p