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    Experimental Study of Partitioning of Lysozyme Enzyme in Aqueous Two-Phase Systems based on Surfactants

    , M.Sc. Thesis Sharif University of Technology Barjasteh, Mahdi (Author) ; Bastani, Dariush (Supervisor) ; Vosoughi, Manochehr (Supervisor)
    Abstract
    In this study, aqueous two-phase systems (ATPS) containing Tween 20 as a biocompatible nonionic surfactant and three different salts (NH4HPO4, NH4CH3COO and Mg(CH3COO)2 ) were prepared and their extractive potential for Lysozyme enzyme was evaluated. These systems have surfactant-rich top phase and salt-rich bottom phase. Phase equilibrium diagrams at 23 ° C were obtained by using the cloud point method and the results were successfully fitted to the Merchuk correlation and their trends were correlated with the effective excluded volume (EEV) parameter. Afterward, the partitioning behavior of the lysozyme and its extraction efficiency in the systems of Tween 20/diammonium hydrogen phosphate,... 

    Experimental Study of Oily Wastewater Treatment by Hybrid Baffled Bioreactor

    , M.Sc. Thesis Sharif University of Technology Zolfaghari, Mehdi (Author) ; Alemzadeh, Iran (Supervisor) ; Vosoughi, Manochehr (Supervisor)
    Abstract
    Oil refineries, petrochemical factories and oil platforms produce a large amount of oily wastewater every day. If these wastewaters are released in environment, it can damage soil and water seriously. Although, Biological treatment of oily wastewaters is a well-established method for remediation of these wastes, efficiency of conventional systems such as Activated Sludge, aren’t very high. Also these systems have many problems such as instability during hydraulics shocks and bulking phenomena. the hybrid bioreactor system are designed to increase the efficiency of treatment by allowing greater organic loads, increasing microbial concentration by using attached and suspended bacteria, and... 

    Investigation of Activation Mechanism of Mechanosensitive Nano Ion Channels

    , Ph.D. Dissertation Sharif University of Technology Bavi, Omid (Author) ; Vosoughi, Manochehr (Supervisor) ; Jamali, Yusef (Supervisor) ; Naghdabadi, Reza (Supervisor)
    Abstract
    Mechanosensitive (MS) channels are ubiquitous molecular force sensors that respond to a number of different mechanical stimuli including tensile, compressive and shear stress. One of the main mechanisms to functionally study these channels is the patch clamp technique. Here we use continuum mechanics to probe the question of how curvature, in a standard patch clamp experiment, at different length scales (global and local) affects a model MS channel. Firstly, to increase the accuracy of the Laplace’s equation in tension estimation in a patch membrane and to be able to more precisely describe the transient phenomena happening during patch clamping, we propose a modified Laplace’s equation. In... 

    Combining Market Segmentation and Customer Segmentation Using Three-factor Theory: the Telecom (MCI) Case Study

    , M.Sc. Thesis Sharif University of Technology Nabizadeh, Mohammad (Author) ; Najmi, Manochehr (Supervisor)
    Abstract
    Mobile and wireless services industry has been among the most attractive businesses recently and is progressing at a fast pace. In this huge industry various organizations and entities cooperate to deliver value to the end user. The mobile operator plays the pivotal role in this chain. Hence mobile operator’s market was chosen in this study as the representative of the industry. Market segmentation and customer satisfaction are the main topics of this study.
    Market segmentation for MCI was done using data mining with two-step algorithm. Input data included the consumer behavior extracted from mobile post-paid bills. The results indicated five distinctive clusters. The next part included... 

    Fabrication of Vertically Oriented TiO2 Nanotube Arrays Using Organic Electrolytes

    , M.Sc. Thesis Sharif University of Technology Hamedi, Mojtaba (Author) ; Askari, Masoud (Supervisor) ; Hakim, Manochehr (Supervisor)
    Abstract
    Titanium dioxide, due to its specific semiconductive properties, has been a highly investigated material for a variety of applications including gas sensors, hydrogen generation by water photoelectrolysis, photocatalysis, dye-sensitized solar cells and purification of water and air. Several recent studies have indicated that titania nanotubes have improved properties compared to any other form of titania for mentioned application. Titania nanotubes have been produced by a variety of methods including deposition into a template and hydrothermal processes. Anodic oxidation of titanium foil in a fluoride-based solution is one of the best methods to produce of titania nanotube arrays. Highly... 

    Neutron Noise Calculation using Nodal Expansion Method

    , M.Sc. Thesis Sharif University of Technology Vosoughi, Javad (Author) ; Vosoughi, Naser (Supervisor) ; Hosseini, Abolfazl (Co-Advisor)
    Abstract
    The present M.Sc. thesis consists of two sections including the static calculation and neutron noise calculation in rectangular and hexagonal geometries. The multi-group, two dimensional neutron diffusion equations and corresponding adjoint equations are solved in the static calculation. The spatial discretization of equations is based on Average Current Nodal Expansion Method (ACNEM). Size of nodes is the same size of the fuel assemblies in modeling both of rectangular and hexagonal geometries. The results are benchmarked against the valid results for BIBLIS-2D and IAEA-2D benchmark problems. In the second section, neutron noise calculations are performed for two types of noise sources,... 

    Mechanisms of Conjugated Linoleic acid and Enriched Glycerides Production as Neutraceuticals Food

    , Ph.D. Dissertation Sharif University of Technology Kouchak Yazdi, Zahra (Author) ; Alemzadeh, Iran (Supervisor) ; Vossughi, Manochehr (Co-Advisor)
    Abstract
    Dietary CLA production for medicinal purposes needs a safe and selective process. Biological production methods meet this goal. In this study, the microbial species that was suitable for CLA production was selected; then the CLA produced by bioconversion methods was utilized to produce CLA-enriched triglycerides by trans-esterification. Also the biochemical kinetics of CLA production and esterification reactions to produce CLA-enriched triglycerides was studied. In the presence of two substrates, the kinetics of enzymatic reaction was studied. Then the factors influencing on the microbial yield and CLA production including reaction conditions (reaction time, cell concentration and substrate... 

    Using Surface Properties of Immiscible Fluids in Capillary Tubes for Identification and Separation of Cancerous Blood Cells

    , M.Sc. Thesis Sharif University of Technology Alinejad, Amin (Author) ; Ayatollahi, Shahabodin (Supervisor) ; Vossoughi, Manochehr (Supervisor)
    Abstract
    Cancer has been known as one of the main reasons for disease-related deaths in the last decades. Early diagnosis could significantly reduce the level of fatality chances. Among the known cancer types, lung cancer is one of the most malignant ones. The common diagnosticmethods are expensive and using high-technology methods; therefore, the introduction of simple and cheap methods is very urgent to detect it. In this project, surface and interfacial tension measurement of cancerous and normal lung cells have been investigated as an easy detection technique. Among the common measurement methods, Pendant Drop and Capillary height techniques have been utilized in this research work. The obtained... 

    Expremental Studying and Thermodynamic Modeling of Separation of Amino Acids by Ionic Liquids

    , M.Sc. Thesis Sharif University of Technology Nazem, Hadi (Author) ; Ghotbi, Cyrus (Supervisor) ; Taghikhani, Vahid (Supervisor) ; Vosoghi, Manochehr (Supervisor)
    Abstract
    In this work, partitioning of amino acids such as glutamic acid, phenyl anine and tryptophan in aqueous and ionic liquid phases at 298.15 K and atmospheric pressure was measured. [C4mim][Tf2N] is used due can produce two phase with water rapidly. Studying the effect of liquid solution pH on amino acids partitioning shows that increasing of pH results in decreasing of amino acid partitioning coefficient. This phenomenon pertains to electrostatic interactions between cation of amino acid and anion of ionic liquid which reduces when pH increases. Considering the effect of pH, liquid-liquid equilibrium data of amino acids was obtained in a pH that owning maximum partioning coefficient. Chemical... 

    Magnetic Resonance Imaging Scan Time Reduction

    , M.Sc. Thesis Sharif University of Technology Alviri, Mohammad Reza (Author) ; Vosoughi, Naser (Supervisor) ; Vosoughi Vahdat, Bijan (Supervisor)
    Abstract
    Magnetic resonance imaging (MRI) is a highly efficient method that can provide acceptable contrast between soft tissues. But the big disadvantage of this method is that its acquisition is slow. To find the reason of being time-consuming should the procedure be surveyed. In the magnetic resonance imaging, location information obtained using phase and frequency encoding gradients. So the output is matrix of image data in the frequency domain, which is called k space. For the formation of the k space phase, need to apply gradients several times and this is the main reason of dullness of the system. Therefore, in this project using software methods try to reduce the scan time as possible. Among... 

    hysical and Chemical Surface Modification of Titanium by Nanostructured Materials, and Biological Characterization for Use in Bone Tissue Implants

    , Ph.D. Dissertation Sharif University of Technology Rahnamaee, Yahya (Author) ; Bagheri, Reza (Supervisor) ; Vossoughi, Manochehr (Supervisor) ; Samadi Kuchaksaraei, Ali (Supervisor)
    Abstract
    According to human needs and in line with the development of advanced technologies, different biomedical Engineering fields like hard tissue implants are growing rapidly. Despite significant biotechnology Developments in recent years, some problems to the recognition of implants related osseointegration phenomena persist. The deficient osseointegration and implant-associated infections are key issues for the long-term clinical success of titanium and titanium alloy implants, while development of multifunctional surfaces that can simultaneously overcome these problems remains highly challenging. Therefore, the ultimate goal of this paper was to improve bone cell attachment and simultaneously... 

    , Ph.D. Dissertation Sharif University of Technology Hosseini, Abolfazl (Author) ; Vosoughi, Naser (Supervisor)
    Abstract
    The present ph.D. thesis consists of three sections including the static calculation, neutron noise calculation and neutron noise source unfolding in VVER-1000 reactor core. The multi-group, two dimensional neutron diffusion equations and corresponding adjoint equations are solved in the static calculation. The spatial discretization of equations is based on Galerkin Finite Element Method (GFEM) using unstructured triangle elements generated by Gambit software. The static calculation is performed for both linear and quadratic approximations of shape function; baesd on which results are compared. Using power iteration method for the static calculation, the neutron and adjoint fluxes with the... 

    , M.Sc. Thesis Sharif University of Technology Zamzamian, Mehrdad (Author) ; Vosoughi, Nasser (Supervisor)
    Abstract
    High purity Germanium (HPGe) detector is a sub branch of semiconductor detectors which has very good resolution, very little dead time, able tobuild in large dimensions and suitable for any condition that it is using in vast fields from space investigation to radiation therapy. this detector is usually used to detecting gamma radiations furthermore the best resolution can be attained with decreasing leakage current. for analyzing about operation of the HPGe detector, it needs to initiate a model of this detector. in this studing has been used modelGEM-15190,POP-TOP which is built by ortec company. for initiating, it was used liquid nitrogen and accessory equipments like high voltage supply,... 

    Unfolding of the Gamma-Ray Spectrum of the Scintillator Detectors Using the Neural Network Method

    , M.Sc. Thesis Sharif University of Technology Pezeshki, Ali (Author) ; Vosoughi, Naser (Supervisor)
    Abstract
    The analysis of gamma-ray spectra of low resolution detectors is difficult and sometimes impossible, as a result of photo peak’s overlapping. The usual methods of radiation spectra analysis based on fitting of peaks to mathematical curves or detecting of peaks with numerical calculation, are valid for high resolution detectors. However these methods are less successful for lower resolution detectors such as the common scintillators. The wide peaks in the spectrum maybe overlap and make it difficult to analysis. To solve this problem, we test here a method, based on the use of the artificial neural network. At first spectra of elements are converted to the patterns which are suitable for the... 

    Calculation of Pulse Height Distribution by Deterministic and Monte Carlo Methods

    , M.Sc. Thesis Sharif University of Technology Akhavan, Azade (Author) ; Vosoughi, Naser (Supervisor)
    Abstract
    Radiation detection techniques have important applications including prompt gamma neutron activation analysis (PGNAA), radiotherapy dose measurement, medical imaging and homeland security. Pulse height distribution is also a useful parameter in Radionuclide identification. Gamma ray spectroscopy analysis is a common technique in measuring of radiation field to identify the radioactive source.
    Probabilistic methods are commonly used for numerical simulation of Pulse height distribution. In Monte Carlo methods, each history is individually tracked and details of interactions are available. Using the Monte Carlo methods for calculation of pulse height distribution leads to more real... 

    Control of Locomotion in a Two-Leg Robot with Uncertain Frictional Effects

    , M.Sc. Thesis Sharif University of Technology Khodabakhsh, Mohammad (Author) ; Vosoughi, Golamreza (Supervisor)
    Abstract
    Microrobots design and manufacturing has been one of interesting fields in robotics in recent decades. They have been designed in various types so far. In this paper a two-leg microrobot is simulated and controlled by using LuGre friction model.
    The proposed microrobot is driven by a piezoelectric actuator mounted between centers of two legs. The piezoelectric is actuated by a frequency near the natural frequency of the robot. The nonlinear dynamical equations of the system are obtained considering LuGre friction model. To control the system, the equations of motion are linearized using feedback linearization method. Then a stabilizing control law is designed and the robot model is... 

    Noise Characterization in VVER-1000 Reactor Core

    , M.Sc. Thesis Sharif University of Technology Nassiri, Ahmad (Author) ; Vosoughi, Naser (Supervisor)
    Abstract
    Neutron fluctuations in both low and high power reactors provide important information about the system. The origins of these fluctuations are different in both regimes. In low power the branching process is the reason of these fluctuations. But the random nature of technological processes such as boiling in the reactors cooling and mechanical structure vibrating such as control rod and fuel rod created the neutron noise. Mathematical descriptions and applications of neutron noise for each mode are different. In common mode, fluctuations in the neutron detection system, determine some parameters and determin the start abnormality in system. In this study the spatial dependence of the cross... 

    Source Localization by Analysis the Response of Detectors Using Inverse Methods

    , M.Sc. Thesis Sharif University of Technology Mechershavi, Fatemeh (Author) ; Vosoughi, Naser (Supervisor)
    Abstract
    Localization of a neutron point source using a designed computer program namely “MCMC-MATURE” is performed. The computer program analyses several detector responses in some certain media by Markov Chain Monte Carlo (MCMC) method and a new iteration algorithm. Identification of the possible regions of source position would be found by analyzing the initial fluxes generated by mesh tally of MCNPX computer code. The designed computer program is capable to generate the flux between detectors. “Regular-Sequential”, “Irregular-Sequential” and “Non-Sequential” are three methods used for sampling the generated random number in two dimensions. Each sample multiplied by a sampling function and lead to... 

    Cooperative Control of a Quadrotor and a Mobile Robot

    , M.Sc. Thesis Sharif University of Technology Manzouri, Alireza (Author) ; Vosoughi, Gholamreza (Supervisor)
    Abstract
    In this project, the final goal is to create a team consisting of a UGV and a quadrotor capable of relative tracking and coordinated landing, with focus on quadrotor control. What we mean by cooperative control in this project is control of quadrotor for the purpose of cooperation with a UGV; This should not be mistaken with another sense of cooperative control in which the control algorithms are developed for both of the robots or are based on the interactive dynamics of the robots.In order to accomplish this goal, an experimental testbed consisting of a quadrotor and a UGV capable of communication and data exchange was developed as a first step. The quadrotor was constructed using... 

    Spatiotemporal Modeling & Simulation of the Second Order Moments of the Transport Equation

    , Ph.D. Dissertation Sharif University of Technology Ayyoubzadeh, Mohsen (Author) ; Vosoughi, Naser (Supervisor)
    Abstract
    Precise knowledge of the laws which govern a system is of interest for two reasons. First, it paves the way to understand the subtle behaviors of the system, which are not understandable from simpler models of the system. Second, it helps in the design of experimental requirements needed to observe these behaviors. The behavior of neutrons in a system, which could be a reactor or a detector, is stochastic from two perspectives. First of all, since the place of the atoms of a medium are randomly sited, at least from a neutrons point of view, the collision sites are random places, which contributes to the stochasticity of the transport phenomena. This type of randomness is somewhat similar to...