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Mechanisms of Conjugated Linoleic acid and Enriched Glycerides Production as Neutraceuticals Food
, Ph.D. Dissertation Sharif University of Technology ; Alemzadeh, Iran (Supervisor) ; Vossughi, Manochehr (Co-Advisor)
Abstract
Dietary CLA production for medicinal purposes needs a safe and selective process. Biological production methods meet this goal. In this study, the microbial species that was suitable for CLA production was selected; then the CLA produced by bioconversion methods was utilized to produce CLA-enriched triglycerides by trans-esterification. Also the biochemical kinetics of CLA production and esterification reactions to produce CLA-enriched triglycerides was studied. In the presence of two substrates, the kinetics of enzymatic reaction was studied. Then the factors influencing on the microbial yield and CLA production including reaction conditions (reaction time, cell concentration and substrate...
Combining Market Segmentation and Customer Segmentation Using Three-factor Theory: the Telecom (MCI) Case Study
, M.Sc. Thesis Sharif University of Technology ; Najmi, Manochehr (Supervisor)
Abstract
Mobile and wireless services industry has been among the most attractive businesses recently and is progressing at a fast pace. In this huge industry various organizations and entities cooperate to deliver value to the end user. The mobile operator plays the pivotal role in this chain. Hence mobile operator’s market was chosen in this study as the representative of the industry. Market segmentation and customer satisfaction are the main topics of this study.
Market segmentation for MCI was done using data mining with two-step algorithm. Input data included the consumer behavior extracted from mobile post-paid bills. The results indicated five distinctive clusters. The next part included...
Market segmentation for MCI was done using data mining with two-step algorithm. Input data included the consumer behavior extracted from mobile post-paid bills. The results indicated five distinctive clusters. The next part included...
In-situ Pb2+ remediation using nano iron particles
, Article Journal of Environmental Health Science and Engineering ; Volume 13, Issue 1 , 2015 ; 2052336X (ISSN) ; Shamsai, A ; Vossughi, M ; Sharif University of Technology
BioMed Central Ltd
2015
Abstract
Originally, application of nano zero valent iron (nZVI) particles for the removal of lead (Pb2+) in porous media was studied. At first, stabilized nZVI (S-nZVI) was prepared and characterized, then used in batch and continuous systems. Based on the batch experiments, corresponding reaction kinetics well fitted with the pseudo-first-order adsorption model, and reaction rate ranged from 0.01 to 0.04 g/mg/min depend on solution pH and the molar ratio between Fe and Pb. In batch tests, optimal condition with more than 90% removal efficiency at 60 min was observed at a pH range of 4 to 6 and Fe/Pb ratio more than 2.5. Continuous experiments exposed that Pb2+ remediation was as well influenced by...
Estimation of human lower extremity musculoskeletal conditions during backpack load carrying
, Article Scientia Iranica ; Volume 16, Issue 5 B , 2009 , Pages 451-462 ; 10263098 (ISSN) ; Meghdari, A ; Vossughi, G. R ; Sharif University of Technology
2009
Abstract
This paper focuses on the biomechanical aspects of the human lower extremity loading condition during backpack load carrying. A biomechanical framework was generated with the aim of employing a block-oriented structure of Simulink integrated with the Virtual Reality Toolbox of MATLAB software to provide a simulation study of the musculoskeletal system in a virtual environment. In this case, a ten-degrees-of-freedom musculoskeletal model actuated with sixteen muscles in each leg was utilized to simulate movement in the sagittal plane. An inverse dynamics based optimization approach was employed to estimate the excitation level of the muscles. In addition, distributions of the mechanical power...
Fabrication of Vertically Oriented TiO2 Nanotube Arrays Using Organic Electrolytes
, M.Sc. Thesis Sharif University of Technology ; Askari, Masoud (Supervisor) ; Hakim, Manochehr (Supervisor)
Abstract
Titanium dioxide, due to its specific semiconductive properties, has been a highly investigated material for a variety of applications including gas sensors, hydrogen generation by water photoelectrolysis, photocatalysis, dye-sensitized solar cells and purification of water and air. Several recent studies have indicated that titania nanotubes have improved properties compared to any other form of titania for mentioned application. Titania nanotubes have been produced by a variety of methods including deposition into a template and hydrothermal processes. Anodic oxidation of titanium foil in a fluoride-based solution is one of the best methods to produce of titania nanotube arrays. Highly...
Experimental Study of Partitioning of Lysozyme Enzyme in Aqueous Two-Phase Systems based on Surfactants
, M.Sc. Thesis Sharif University of Technology ; Bastani, Dariush (Supervisor) ; Vosoughi, Manochehr (Supervisor)
Abstract
In this study, aqueous two-phase systems (ATPS) containing Tween 20 as a biocompatible nonionic surfactant and three different salts (NH4HPO4, NH4CH3COO and Mg(CH3COO)2 ) were prepared and their extractive potential for Lysozyme enzyme was evaluated. These systems have surfactant-rich top phase and salt-rich bottom phase. Phase equilibrium diagrams at 23 ° C were obtained by using the cloud point method and the results were successfully fitted to the Merchuk correlation and their trends were correlated with the effective excluded volume (EEV) parameter. Afterward, the partitioning behavior of the lysozyme and its extraction efficiency in the systems of Tween 20/diammonium hydrogen phosphate,...
Experimental Study of Oily Wastewater Treatment by Hybrid Baffled Bioreactor
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor) ; Vosoughi, Manochehr (Supervisor)
Abstract
Oil refineries, petrochemical factories and oil platforms produce a large amount of oily wastewater every day. If these wastewaters are released in environment, it can damage soil and water seriously. Although, Biological treatment of oily wastewaters is a well-established method for remediation of these wastes, efficiency of conventional systems such as Activated Sludge, aren’t very high. Also these systems have many problems such as instability during hydraulics shocks and bulking phenomena. the hybrid bioreactor system are designed to increase the efficiency of treatment by allowing greater organic loads, increasing microbial concentration by using attached and suspended bacteria, and...
Dynamics Modeling of new Scratch-drive Actuators with Bounce back Mechanism (BSDA)
, M.Sc. Thesis Sharif University of Technology ; Vossughi, Gholamreza (Supervisor) ; Meghdari, Ali (Supervisor)
Abstract
In recent decades, micro-electromechanical systems – MEMS – havefound extensive applications in applied science and engineering. One of the most popular MEMS actuatorsis micro Scratch Drive Actuator (SDA), which can be used in various applications, for instance: precision positioning, micro-chip displacement and rotating micromotors. Their outstanding capabilities such as: high controllability, precise step displacement, vast transportation domain and large force relative to their small size, have made them popular among researchers. Recently, a new generation of SDA is introduced, known as Bounce-back Scratch Drive Actuator or BSDA, which is fundamentally different in motion generation from...
Design of a Setup for Simultaneous Control of Multiple Magnetic Microrobots
, Ph.D. Dissertation Sharif University of Technology ; Nejat Pishkenari, Hossein (Supervisor) ; Vossughi, Gholamreza (Co-Supervisor)
Abstract
Microrobots (MRs) have attracted a lot of attention during recent years due to their promising biomedical applications. Due to their small size, these robots have limited capability to carry energy sources, sensors, or actuators, so researchers try to transfer energy from outside as much as possible. For this purpose, various actuation methods such as optical, acoustic, electric, and magnetic have been proposed. Magnetic field is the most used energy source. The current study deals with the design and implementation of a system for simultaneous independent control of multiple swimming magnetic MRs. The ability to control multiple MRs simultaneously and independently could lead to higher...
Using Surface Properties of Immiscible Fluids in Capillary Tubes for Identification and Separation of Cancerous Blood Cells
, M.Sc. Thesis Sharif University of Technology ; Ayatollahi, Shahabodin (Supervisor) ; Vossoughi, Manochehr (Supervisor)
Abstract
Cancer has been known as one of the main reasons for disease-related deaths in the last decades. Early diagnosis could significantly reduce the level of fatality chances. Among the known cancer types, lung cancer is one of the most malignant ones. The common diagnosticmethods are expensive and using high-technology methods; therefore, the introduction of simple and cheap methods is very urgent to detect it. In this project, surface and interfacial tension measurement of cancerous and normal lung cells have been investigated as an easy detection technique. Among the common measurement methods, Pendant Drop and Capillary height techniques have been utilized in this research work. The obtained...
Investigation of Activation Mechanism of Mechanosensitive Nano Ion Channels
, Ph.D. Dissertation Sharif University of Technology ; Vosoughi, Manochehr (Supervisor) ; Jamali, Yusef (Supervisor) ; Naghdabadi, Reza (Supervisor)
Abstract
Mechanosensitive (MS) channels are ubiquitous molecular force sensors that respond to a number of different mechanical stimuli including tensile, compressive and shear stress. One of the main mechanisms to functionally study these channels is the patch clamp technique. Here we use continuum mechanics to probe the question of how curvature, in a standard patch clamp experiment, at different length scales (global and local) affects a model MS channel. Firstly, to increase the accuracy of the Laplace’s equation in tension estimation in a patch membrane and to be able to more precisely describe the transient phenomena happening during patch clamping, we propose a modified Laplace’s equation. In...
Expremental Studying and Thermodynamic Modeling of Separation of Amino Acids by Ionic Liquids
, M.Sc. Thesis Sharif University of Technology ; Ghotbi, Cyrus (Supervisor) ; Taghikhani, Vahid (Supervisor) ; Vosoghi, Manochehr (Supervisor)
Abstract
In this work, partitioning of amino acids such as glutamic acid, phenyl anine and tryptophan in aqueous and ionic liquid phases at 298.15 K and atmospheric pressure was measured. [C4mim][Tf2N] is used due can produce two phase with water rapidly. Studying the effect of liquid solution pH on amino acids partitioning shows that increasing of pH results in decreasing of amino acid partitioning coefficient. This phenomenon pertains to electrostatic interactions between cation of amino acid and anion of ionic liquid which reduces when pH increases. Considering the effect of pH, liquid-liquid equilibrium data of amino acids was obtained in a pH that owning maximum partioning coefficient. Chemical...
hysical and Chemical Surface Modification of Titanium by Nanostructured Materials, and Biological Characterization for Use in Bone Tissue Implants
, Ph.D. Dissertation Sharif University of Technology ; Bagheri, Reza (Supervisor) ; Vossoughi, Manochehr (Supervisor) ; Samadi Kuchaksaraei, Ali (Supervisor)
Abstract
According to human needs and in line with the development of advanced technologies, different biomedical Engineering fields like hard tissue implants are growing rapidly. Despite significant biotechnology Developments in recent years, some problems to the recognition of implants related osseointegration phenomena persist. The deficient osseointegration and implant-associated infections are key issues for the long-term clinical success of titanium and titanium alloy implants, while development of multifunctional surfaces that can simultaneously overcome these problems remains highly challenging. Therefore, the ultimate goal of this paper was to improve bone cell attachment and simultaneously...
Design and Construction of Alginate-Silica Nanocomposite and Its Application for Mammalian Cell Culture
, M.Sc. Thesis Sharif University of Technology ; Vossughi, Manouchehr (Supervisor) ; Arpanaei, Ayyoob (Supervisor) ; Kabir Salmani, Maryam (Co-Advisor)
Abstract
Three sizes of silica nanoparticles (160±7, 450±10 and 600±25) were sythetized via template-removing method. The synthetized nanoparticles were functionalized with N-(2-aminoethyl)-3-aminopropyl trimethoxy-silane (EDS) to provide a positive charge on the surface of nanoparticles. BET analysis showed that the average pore diameter, surface area and pore volume of nanoparticles were 2.3 nm, 769 m2.g-1 and 0.44 cm3.g-1, respectively. showed that the Amine-functionalized silica nanoparticles were used to enhance the application of alginate polymer for 3D encapsulation of mammalian cells. Incorporating of silica nanoparticles can be suitable for the bead integrity and attachement of mammalian...
Design and Fabrication of Centrifugal Microfluidic System to Measure Blood Factors
, M.Sc. Thesis Sharif University of Technology ; Saadatmand, Maryam (Supervisor) ; Eghbal, Manochehr (Supervisor) ; Bakhtiari, Mohammad Reza (Co-Advisor)
Abstract
Diabetes mellitus is a global endemic that is rapidly increasing prevalence in both developing and developed countries. Recently, the American Diabetes Association has recommended the hemoglobin A1c as a possible substitute to fasting blood glucose for diagnosis of diabetes because it is an indicator of long-term glycemic control. Also, centrifugal microfluidics systems have a good potential to be used in the point of care testing systems. In this study, two centrifugal microfluidic discs were designed and manufactured in order to separately measure the hemoglobin and hemoglobin A1c in the whole blood. In the first part of the study, the hemoglobin measurement disc consists of two chambers...
Experimental Investigation of CO2-Oil Relative Permeability
, M.Sc. Thesis Sharif University of Technology ; Vossughi, Manouchehr (Supervisor) ; Shadizadeh, Reza (Supervisor) ; Kharrat, Reyaz (Supervisor) ; Ghazanfari, Mohammad Hossain (Co-Advisor)
Abstract
Relative permeability is an important factor that controls the two phase fluid flow in porous media. The use of carbon dioxide in enhanced oil recovery methods is common. But the question is, how does the carbon dioxide affect the relative permeability curves? In this thesis, the CO2-oil relative permeability is measured in CO2 flooding process with unsteady state method. For this purpose, the core flooding apparatus is used and the results are compared with N2-oil relative permeability in N2 flooding. The results of comparison show that oil relative permeability in CO2 flooding is higher than N2 flooding. Reduction of Interfacial tension and oil viscosity, solubility of CO2 in oil and oil...