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Design Low Power Carry Skip Adder with Gate Diffusion Input Technique
, M.Sc. Thesis Sharif University of Technology ; Hajsadeghi, Khosrow (Supervisor)
Abstract
The purpose of this thesis is designing and implementation of a Carry Skip Adder using CMOS traditional technology and Gate Diffusion Input technique (GDI). I present a carry skip adder (CSKA) structure that has a higher speed, lower energy consumption compared with the conventional one. The Gate Diffusion Input is a novel technique for low power digital circuit design. This technique reduces the power dissipation, propagation delay, area of digital circuits and it maintains low complexity of logic design
Design and Analysis of a Cell Injection Manipulator Made of a Piezo-Driven Double-Deck Stewart Platform
, M.Sc. Thesis Sharif University of Technology ; Ahmadiyan, Mohammad Taghi (Supervisor)
Abstract
With respect to the introduction of bio-material into cells (transfection) , microinjection is a highly efficient technique amongst existing methodologies. In cell injection, a manipulator injects the needle into a cellwhich is hold by a pipet mechanism. The moving range for the needle in this operation is of centimeter order and the resolution for the needle tip should be less than the cell’s diameter. In this thesis a Stewart system is used as for the manipulator. Stewart systems are used in flight simulators systems for decades, as mechanisms which are capable of providing multi-axis movements. In high accuracy positioning and multi-axis applications Stewart systems are highly reliable....
Wire-Based friction stir processing as a novel pathway for solid-state surface alloying of magnesium
, Article Metallurgical and Materials Transactions A: Physical Metallurgy and Materials Science ; Volume 52, Issue 11 , 2021 , Pages 4737-4741 ; 10735623 (ISSN) ; Mousavizade, S. M ; Pouranvari, M ; Sharif University of Technology
Springer
2021
Abstract
Wire-based friction stir processing is introduced as a solid-state surface alloying strategy for surface alloying of AZ31 magnesium alloy with aluminum, as a key alloying element in magnesium alloys. This technique enables the formation of a defect-free, grain refined and alloyed surface with the increased volume fraction of Mg-Al second phase, and thus, enhanced surface hardness. This simple technique provides a solid-state surface alloying pathway to improve the surface properties of the metallic materials. © 2021, The Minerals, Metals & Materials Society and ASM International
The Effect of Interlayer Thickness on Microstructure and Mechanical Properties of TLP Bonding on Dual Phase Steel
, M.Sc. Thesis Sharif University of Technology ; Ekrami, Ali Akbar (Supervisor)
Abstract
In this study, the effect of the Cu interlayer thickness was studied on St52 steel. Specimens with different thickness of the interlayer, were subjected to 1150 °C at different times. Isothermal solidification was completed for the thickness of the 50 μm, 30 μm, and 10 μm in 30, 25 and 20 minutes. Afterwards, homogenizing and dual-phase heat treatment were used for 75 minutes at 730°C. Optical microscopy and SEM were used to analyze the microstructure of the joints. Mechanical properties of the joints, including micro hardness of different parts of the joint and also shear strength of the joint zone were studied. The results show that after homogenizing treatment, microstructure and harness...
Model Based Testing in Software Product Line
, M.Sc. Thesis Sharif University of Technology ; Mirian-Hosseinabadi, Hassan (Supervisor)
Abstract
Software product line (SPL) engineering offers several advantages such as reduced costs, high quality and less time to market in development of family of software products. The goal of software product line is systematic and effective development of a set of software products which share common and managed set of features. Software product line testing has its special challenges such as scalability and variability, and has significant importance due to the importance of quality in software product line and enormous number of possible products. Most of the popular methods in this domain have shortcomings such as having seam between development and testing processes, limited application scope...
AntAngioCOOL: computational detection of anti-angiogenic peptides
, Article Journal of Translational Medicine ; Volume 17, Issue 1 , 2019 ; 14795876 (ISSN) ; Khorsand, B ; Yousefi, A. A ; Kargar, M. J ; Shirali Hossein Zade, R ; Mahdevar, G ; Sharif University of Technology
BioMed Central Ltd
2019
Abstract
Background: Angiogenesis inhibition research is a cutting edge area in angiogenesis-dependent disease therapy, especially in cancer therapy. Recently, studies on anti-angiogenic peptides have provided promising results in the field of cancer treatment. Methods: A non-redundant dataset of 135 anti-angiogenic peptides (positive instances) and 135 non anti-angiogenic peptides (negative instances) was used in this study. Also, 20% of each class were selected to construct an independent test dataset (see Additional files 1, 2). We proposed an effective machine learning based R package (AntAngioCOOL) to predict anti-angiogenic peptides. We have examined more than 200 different classifiers to build...
afpCOOL: a tool for antifreeze protein prediction
, Article Heliyon ; Volume 4, Issue 7 , 2018 ; 24058440 (ISSN) ; Shirali Hossein Zade, R ; Takalloo, Z ; Mahdevar, G ; Emamjomeh, A ; Sajedi, R. H ; Zahiri, J ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
Various cold-adapted organisms produce antifreeze proteins (AFPs), which prevent the freezing of cell fluids by inhibiting the growth of ice crystals. AFPs are currently being recognized in various organisms, living in extremely low temperatures. AFPs have several important applications in increasing freeze tolerance of plants, maintaining the tissue in frozen conditions and producing cold-hardy plants by applying transgenic technology. Substantial differences in the sequence and structure of the AFPs, pose a challenge for researchers to identify these proteins. In this paper, we proposed a novel method to identify AFPs, using supportive vector machine (SVM) by incorporating 4 types of...
Structural characterization of a rhamnolipid-type biosurfactant produced by Pseudomonas aeruginosa MR01: Enhancement of di-rhamnolipid proportion using gamma irradiation
, Article Colloids and Surfaces B: Biointerfaces ; Volume 81, Issue 2 , 2010 , Pages 397-405 ; 09277765 (ISSN) ; Abassi, H ; Ahmadkhaniha, R ; Roostaazad, R ; Masoomi, F ; Zahiri, H. S ; Ahmadian, G ; Vali, H ; Noghabi, K. A ; Sharif University of Technology
2010
Abstract
We previously reported that MR01, an indigenous strain of Pseudomonas aeruginosa, was able to produce a rhamnolipid-type biosurfactant. Here, we attempted to define the structural properties of this natural product. The analysis of the extracted biosurfactant by thin-layer chromatography (TLC) revealed the presence of two compounds corresponding to those of authentic mono- and di-rhamnolipid. The identity of two structurally distinguished rhamnolipids was confirmed by 1H and 13C nuclear magnetic resonance (NMR) spectroscopy. Liquid chromatography/mass spectrometry (LC/MS) of extracted biosurfactant revealed up to seventeen different rhamnolipid congeners. Further quantification showed...