Sharif Digital Repository

To design a drug delivery system, the drug must be encapsulated within a carrier matrix. One of the main challenges in this field is encapsulating high drug doses while achieving a linear release profile at the target site to maintain drug concentration for optimal therapeutic effects. Consequently, many research groups have focused on refining fabrication techniques to maximize loading efficiency and optimize drug release profiles from delivery systems. A potential approach to addressing this issue is the direct fabrication of a controlled-release system from the active pharmaceutical ingredient (API) itself, eliminating the need for a carrier matrix. Studies have demonstrated that such... 

Feyerabend was a philosopher of science that became famous for his purportedly anarchistic view of science and his rejection of the existence of universal methodological rules and rationality of science. Feyerabend’s view of science can be summarize in a few points; 1. On the issue of falsifiability, Feyerabend argues that no theory is ever consistent with all the relevant facts. He sees the use of ad-hoc postulates to save the dominant paradigm as an essential to the progress of science. He claims that scientists frequently depart completely from the scientific method when they use ad-hoc ideas to explain observations that are only later justified by theory. To Feyerabend, ad-hoc... 

Nowadays, separate use of traditional service management frameworks and approaches will not meet the needs of businesses and customers. This is because of the very fast change in the environment and the move to the digital age. The integration of traditional approaches into modern ones significantly helps organizations adapt to new needs and changes in the environment. In this research, first, the basic concepts of the ITIL framework as the most widely used IT services management framework have been studied. Then, the COBIT framework as the most accepted IT governance framework has been investigated. The VeriSM approach also has been used as a solution for service management in the digital... 

Nowadays, separate use of traditional service management frameworks and approaches will not meet the needs of businesses and customers. This is because of the very fast change in the environment and the move to the digital age. The integration of traditional approaches into modern ones significantly helps organizations adapt to new needs and changes in the environment. In this research, first, the basic concepts of the ITIL framework as the most widely used IT services management framework have been studied. Then, the COBIT framework as the most accepted IT governance framework has been investigated. The VeriSM approach also has been used as a solution for service management in the digital... 

Osteoarthritis is a common musculoskeletal disorder and the most prevalent form of arthritis. To date, no comprehensive cure has been reported for osteoarthritis, and its clinical management remains challenging. The primary therapeutic goals in the early stages of osteoarthritis are to increase joint mobility and control disease progression by continuously releasing drugs and molecules modulating inflammatory responses and reducing pain. Smart drug delivery platforms are one of the strategies to overcome the challenges of injectable and oral medications. Additionally, drug carrier particles can have different therapeutic targets based on their size and shape. Different therapeutic... 

Since oil prices continue to increase, energy conservation remains the prime industrial concern. Existing processes in power plants and oil refineries are not energy efficient as they should be therefore new projects can be defined to increase the energy efficiency without incurring any cost. The most appropriate utility for the processes should be explored to reduce emissions, increase the plant capacities and improve product qualities and energy efficiencies by one coherent strategic plan for the overall site which can be achieved by a full understanding of pinch technology and awareness of the available tools for applying it in practical way. Since the distillation unit of crude oil... 

Macrophages play a crucial role in the healing process of chronic wounds in diabetic patients. These cells polarize from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype, guiding the initial inflammation toward tissue repair and regeneration. In diabetic patients, physiological disturbances impair this polarization, resulting in persistent, chronic, and inflamed wounds. Glucocorticoid anti-inflammatory drugs are commonly used but have serious side effects, necessitating targeted delivery systems. This study aims to design and optimize self-assembled complex coacervate drug delivery system composed of gelatin and sodium alginate (GA/SA CCA) that can selectively uptake by... 

Microelectromechanical sensors are small and sensitive devices that can measure physical quantities such as pressure, temperature, speed, and acceleration. Some of these sensors, which include accelerometers and gyroscopes, are used in small navigation systems. These sensors are highly sensitive and influenced by their surrounding environment, which may malfunction under the influence of some environmental factors; In such a way that the data output from them is accompanied by a significant error. One of the factors causing malfunction of the sensor is the high frequency fluctuations of the environment. In practice, it is not possible to completely eliminate these fluctuations. A logical and... 

Graphene quantum dots (GQDs) as a sort of carbon-based nanomaterials are applied in a multitude of exciting areas. They are effective fluorescent probe for many potential biological and medical applications. In comparison to conventional organic fluorescent probes (organic dyes), GQDs have substantial advantages, such as photostability, excellent solubility, low cytotoxicity and biocompatibility.
In this thesis, green fluorescent GQDs have been prepared via solvothermal method from graphite powder.Various analysis methods were utilized to characterization of the product. So, several experiments on GQDs in solution and in solid substrate at room temperature have been performed. The...