Sharif Digital Repository

Genetic heterogeneity within a tumor, which occurs during cancer evolution, is one of the reasons for treatment failure and increased chances of drug resistance. Cancer cells initially derive from a mutated progenitor cell, resulting in shared mutated genes. Throughout the course of tumor formation and progression, the occurrence of new mutations is possible, leading to the generation of cancer cells with various mutated genes. An appropriate approach is to identify the sequence of mutations that have occurred in the tumor, which can be inferred from single-cell sequencing data. Singlecell data provides valuable information about branching events in the evolution of a cancerous tumor. In... 

The problem of Origination of The Universe is one of the most important issues in the history of philosophy whether in western edition or in Islamic thought. The most problematic aspect of the Origination is Temporal Origination. From about 30 years ago as a result of the works of a famous American philosopher William Lane Craig, the debate between temporality and Eternity of the Universe became a fresh topic in western philosophy. In this research we want to survey the philosophical arguments for and against the temporality of the Universe based on the views of: W.L.Craig, Q.Smith and Allamah S.M.H Al-Tabatabaie.
 

This thesisconsiders new fundamental approaches to yield heterogeneous catalysts in to three sections. The first section described the immobilization of the molybdenum-Schiff base complexes in pores of SBA-15 in two different methodologies depending on the actual structure of the complexes., (i) stepwise formation of the complex by initial covalent anchoring of one of the components and consecutive solid phase synthesis consisting of the condensation of the other components of the salen complex (iii) one-step complex immobilization by covalent binding through the ligand.Based on the first methodology, we report the preparation of ordered mesoporous silica SBA-15 containing a molybdenum... 

The subgradient method is one of the most favoriate methods to solve discrete optimization problems. The Easy Implementation and flexibility enbles us to solve a vast types of complicated combinatorial optimization problems. However, the algorithm can be improved by adjusting its parameters and steps.In present research, we present a heuristic structure to modify and improve the algorithm. Then, the proposed algorithm has tested on special classes of discrete optimization problems such as Generealized Assignment and Uncapacitated Warehouse location problems. The results show that the proposed algorithm can improve the efficiency of the classic form of subgradient method.The three main... 

A complete 6DOF flight dynamic model of an elastic flapping wing (EFW), integrated with unsteady aerodynamic theory is developed. In this respect, initially efficient high fidelity modules for EFW structural dynamics (SD) as well as unsteady aerodynamics loadings (UAL) to be coupled with its flight dynamics are prepared. A modal approach is followed to model structural dynamics of plain and 3D EFWs. This is in contrast with the Euler-Bernoulli beam theory that is mostly utilized for SD in the existing literature. In addition, due to the possibility of large wing deformations as well as the existence of non-linear displacement regime for realistic EFW flights, non-linear modal approaches such... 

With the development of electrical engineering and the electrical industry, the use of copper and its alloys has grown tremendously. On the other hand, with development and modern industry, it will be difficult to meet the requirements such as high performance, cost reduction and weight reduction of the structure if only one metal material is used in the production of the desired component or structure. Aluminum can be used in combination with copper because of its properties such as high thermal and electrical conductivity. Al/Cu bonding is used in industries such as microelectronics, automobiles and batteries. This study has investigated parametrically the feasibility of uneven bonding of... 

In this research, multi-disciplinary design optimization (MDO) of a flying vehicle has been done based on the flight simulation. A meta-heuristic algorithm called Multi-objective Adaptive Real-coded Memetic Algorithm (MARCOMA) has been used for optimization. Since solving a MDO problem is a time consuming process, a RBF neural network has been used in the optimization algorithm as a surrogate model. The new algorithm, called MARCOMA+NN, has been tested with some standard benchmarks. MDO problem has six disciplines consists structure, aerodynamic, propulsion, guidance, control, and fire control. The MDO problem has 31 design variables and two objective functions. The objective functions are... 

A cooperative aerial system to defense a Ground Station (GS), against an Incoming aerial Targets (IT) is presented. GS is surrounded by given terrains and a group of homogenous Unmanned Aerial Vehicles (UAVs) are employed using a novel online guidance algorithm in a decentralized manner. The proposed algorithm includes loiter, midcourse and terminal phases. During loiter; UAVs follow an optimal circular path. IT is supposed to approach GS along an optimal low altitude trajectory with respect to the terrains. UAVs are informed the initial position and velocity of IT and they are unaware of IT trajectory. Each UAV decides on whether to engage with IT or not, and shares its decision with other... 

PVDF (polyvinylidene fluoride) magnetic nanocomposite films were prepared by solution casting using two types of nanomagnetic particles: (i) magnetic nanoparticles synthesized by using an alkaline solution of mixed ferrous/ferric salts along with oleic acid as a coating agent at 70˚C; (ii) Fe3O4 nanoparticles prepared by hydrolysis of aqueous solution of ferrous/ferric salts with potassium hydroxide at room temprature. Scanning electron microscopy (SEM) showed that the PVDF magnetic nanocomposite had a porous structure with Fe3O4 nanoparticles dispersed inside the porous polymer matrix. The presence of crystalline magnetite within the polymer matrix was confirmed by X-Ray diffraction method... 

In this project, a method for cooperative search and localization of RF ground moving targets by a group of UAVs is developed. It should be noted that UAVs are just equipped with GPS and directional sensors. Since there is fuel constraint for UAVs, they take fuel from a tanker whenever they require. Moreover, searching method enables the UAVs to see different parts of the desired area with almost uniform distribution. In addition, the proposed approach enables the UAVs to perform a local search with the aim of finding the targets having lost their signal during localization mode. Finally, based upon a fueling decision function the UAVs take turn, approach to the fuel tanker, and start... 

In this research a novel intelligent back-stepping control method is developed. This method is robust to sensor noise and external disturbances. In addition, the controller is robust under model uncertainty. This controller does not need precise knowledge of system parameters. This method is based on three methods of: back-stepping control, least squares estimation and a fuzzy compensator. This controller is used to control quadrotor stand witch is like an inverse pendulum. In quadrotor stand modeling, the inverse pendulum effect is considered too, witch is one of the innovations of the research. By doing various simulations, the validity of controller is tested. Also the performance of the... 

Topic that is investigated in this article include identify and localization a number of aerial target penetrating into a protected by area by a swarm of UAVs is fixed wing. UAVs do not have any prior notice of positioning targets. In addition, it is assumed that lacks any radiation exploitable targets and thus use UAVs for Targets Detection from an active radar system. Obviously this article focus on developing a guidance algorithm UAVs to this particular issue and also as the targets participatory is localization algorithm. In addition, extraction type and performance characteristics radar system required and also performance characteristics of the class of UAVs, which is suitable to... 

The purpose of this paper is to design an integrated controller and observer (ICO) for a nonlinear system using genetic programming. ICO is a function that constructs control command directly from the measured state variables of the system. It means that, this function should imitate the behavior of the observer and controller and control the system with acceptable performance in different initial conditions, at the presence of disturbances and system uncertainties. The complexity of this design method, is not related to the complexity of the plant, in fact, the complexity in plant just effects at run time, but the design procedure does not change. So, if exact model of plant exist, using... 

Nowdays much of the organic solid waste and wastewater is buried using centralized and traditional methods. This leads to many problems, including groundwater pollution, methane emissions into the atmosphere and rapid transmission of disease. In order to avoid these problems, using a decentralized approach can be a good solution. In this study, recovery of organic waste and wastewater of residential buildings using anaerobic digester as a decentralized way, have been examined. Using experiments, the optimum mass ratio of organic solid waste and wastewater is obtained as 80% and 20% respectively. Biogas production model is developed using mass balance and Balance of electrons in redox... 

Multi-disciplinary design optimization (MDO) of a surface to air flying vehicle has been done in this research, on the basis of flight simulation. The MDO problem have five disciplines consists of aerodynamic, propulsion, guidance, control, and fire control. Multiple campaign scenarios are defined. The MDO problem has 31 design variables and two objective functions. The objective functions are flying vehicle weight and miss distance. A new meta-heuristic algorithm has been designed to solve multi-objective optimization problems. The new algorithm has been called Multi-objective Adaptive Real-coded Memetic Algorithm (MARCOMA). The MARCOMA can solve large-scale and multi-objective problems and... 

In this Thesis, an unmanned multicopter with a new structure is modeled and a nonlinear controller is designed for it to track the trajectories precisely. The multicopter in this thesis, has six propellers with a hybrid propulsion system (a combination of fuel and electric propulsion system) that has the ability to carry more payload and maintain more flight duration compared to electric multicopters. In the beginning, the performance characteristics and technical specifications of the hexacopter are presented. For modeling, first the equations of six degrees of freedom movement of the hexacopter are derived by the Newton-Euler method. In the next step, the forces and torques applied to the...