Production and Quality Control of 225Ac-PSMA and Absorbed Dose Estimation of its in Different Human Organs

, M.Sc. Thesis Sharif University of Technology Rezazadeh Sefideh, Fatemeh (Author) ; Hoseini, Abolfazl (Supervisor) ; Shirvani Arani, Simindokht (Supervisor) ; Zolghadri, Samaneh (Co-Supervisor)

Abstract

Prostate cancer is the second leading cause of cancer-related mortality in men after lung cancer. Prostate-specific membrane antigen (PSMA-617) labeled with Actinium-225 (225Ac) is currently being studied as a potential treatment for metastatic castration-resistant prostate cancer. This study aimed to produce the labeled compound [225Ac]Ac-PSMA-617 for the treatment of prostate cancer and its metastases. The compound was synthesized under optimized labeling conditions, and its radiochemical purity was determined to be over %96 using RTLC chromatography method. The biodistribution of the compound was evaluated in the tissues of healthy male mice, and the injected activity per unit mass of...

Improvement of nanosilica effects on the performance of mechanically processed styrene-butadiene rubber by rational hybridization with nanodiamond

, Article Diamond and Related Materials ; Volume 130 , 2022 ; 09259635 (ISSN) Mohammadi, A ; Shojaei, A ; Khasraghi, Samaneh Salkhi ; Sharif University of Technology

Elsevier Ltd 2022

Abstract

Hybrid nanoparticle comprising of nanosilica (NS) and nanodiamond (ND), denoted by ND@NS, was synthesized by a two-step chemistry route and then incorporated into styrene-butadiene rubber (SBR) at low concentrations up to 5 phr by a two-roll mill. Physical hybrids of NS and ND, i.e., ND&NS, with a weight ratio similar to chemical hybrid (80:20 for NS:ND), were also incorporated into SBR. Field emission scanning electron microscopy observations revealed very fine dispersion of nanoparticles in the case of physical hybrids (ND&NS). In contrast, agglomerations and aggregation of nanoparticles were evidenced for ND@NS. Tensile and dynamic mechanical analyses exhibited a higher reinforcing effect...

An Investigation on the Role of Silica Hybrid Nanoparticles on the Properties of Styrene Butadiene Rubber (SBR)

, M.Sc. Thesis Sharif University of Technology Mohammadi, Ali (Author) ; Shojaei, Akbar (Supervisor) ; Salkhi Khasraghi, Samaneh (Co-Supervisor)

Abstract

Hybrid nanoparticle comprising of nanosilica (NS) and nanodiamond (ND), as denoted by ND@NS, was synthesized by a two-step chemistry route and then incorporated into styrene-butadiene rubber (SBR) at low concentrations up to 5 phr by a two-roll mill. Physical hybrids of NS and ND, i.e., ND&NS, with a weight ratio similar to chemical hybrid (80:20 for NS:ND), were also incorporated into SBR. Field emission scanning electron microscopy observations revealed very fine dispersion of nanoparticles in the case of physical hybrids (ND&NS); whereas, agglomerations and aggregation of nanoparticles were evidenced for ND@NS. Tensile and dynamic mechanical analyses exhibited a higher reinforcing effect...

Synthesis and Investigation of Properties of Biocompatible Polyurethane Acrylate Based Nanocomposites/Cellulose Nanocrystals

, M.Sc. Thesis Sharif University of Technology Beik Mohammadi, Mahbubeh (Author) ; Shojaei, Akbar (Supervisor) ; Salkhi, Samaneh (Co-Supervisor)

Abstract

Bio-based shape memory polymers with fast-response have high potential for use in medical applications. In this study, biocompatible and biodegradable nanocomposites based on shape memory polyurethane acrylates (SMPUA)/cellulose nanocrystals (CNC), were synthesized by in-situ polymerization. CNC is a natural and renewable nanoparticle that has been considered for medical applications due to its excellent mechanical and biological properties and surface chemistry. At the first phase of this study, in order to synthesize UV-curable shape memory polyurethane acrylate, polycaprolactone diol (PCL-Diol), hexamethylene diisocyanate (HDI) and hydroxyethyl methacrylate (HEMA) were used as an reactive...

Synthesis and Evaluation of Poly(lactic Acid)/Polyurethane Nano-composites based on Cellulose Nano-particles, with Biomedical Applications

, M.Sc. Thesis Sharif University of Technology Mohammadian Ahrabi, Taha (Author) ; Shojaei, Akbar (Supervisor) ; Salkhi Khasraghi, Samaneh (Co-Supervisor)

Abstract

Shape memory polymers have the potential to use in the field of biomedical applications. In this research, polyurethane structures have been synthesized based on the Diol mixtures, consisting of polycaprolactane diol (PCL-diol) and poly (lactic acid) diol (PLA-diol). Aim of reasearch is about evaluating poly (lactic acid) effect in structure of the polyurethane. At the same time, cellulose nanocrystals (CNC) have been added to polymer matrix to improve properties. The synthesis of acrylated polyurethane, included the synthesis of polyurethane acrylate prepolymer. Next, this prepolymer has been cured by adding the reactive diluent and some polyol. The cured systems were investigated, finally,...

Synthesis and Investigation of Metal–Organic Framework (MOF) on Properties of Biocompatible Polyurethane Acrylate

, M.Sc. Thesis Sharif University of Technology Salavati, Ali (Author) ; Shojaei Segherlou, Akbar (Supervisor) ; Salkhi Khasraghi, Samaneh (Co-Supervisor)

Abstract

The objective of this research is to evaluate different morphologies of UiO-66 structures (pristine state and UiO-66 structure chemically supported on graphene oxide (UiO-66@GO)), on the rheology of polyurethane acrylate nanocomposites prior to UV-curing. The synthesized nanoparticles were characterized by FTIR, FESEM, TGA, XRD, and BET analysis. Rheological investigations, including large amplitude oscillatory sweep, small amplitude oscillatory sweep, steady shear flow, and thixotropic analysis were utilized. Moreover, the obtained rheological results were fitted using the Carreau–Yasuda model, the power-law model, and the Herschel–Bulkley model for quantitative interpretations. The results...

Investigation the Rule of Carbon-Based Quantum Dot on Biocompatible Polyurethane Acrylate

, M.Sc. Thesis Sharif University of Technology Fahimifar, Hamid Reza (Author) ; Shojaei, Akbar (Supervisor) ; Salkhi Khasraghi, Samaneh (Supervisor)

Abstract

Biocompatible materials play a fundamental role in the advancement of medical science and provide groundbreaking solutions for tissue engineering and various therapeutic applications. Among these materials, polyurethane acrylate has attracted attention due to its biocompatibility, versatility, and suitability for creating complex medical scaffolds. This research investigates an innovative approach to reinforce polyurethane acrylate by incorporating graphene quantum dots, with the aim of developing advanced scaffolds for tissue engineering. The incorporation of graphene quantum dots is designed to take advantage of their exceptional properties to improve the mechanical strength, thermal...

Design of Medium Voltage Cascaded H Bridge Multilevel Inverter with Reliability Consideration

, M.Sc. Thesis Sharif University of Technology Balador, Ayoub (Author) ; Zolghadri, Mohammad Reza (Supervisor)

Abstract

Today, with the development of power electronics and the emergence of various multilevel converters, possibility of operation at the voltage and powers higher than the rated value of components is provided. The reliability of these converters due to their high power is important. In this project, design of multilevel inverter with cascaded H-bridge structure have been studied for a medium voltage and high power 3.3 KV, 1MVA application, due to its advantages over other structures. This converter is composed of several cascaded low voltage full-bridge cells. Therefore, the converter is composed of many semiconductor elements that the reliability of them depends on the physical stresses such...

Model Predictive Controller Design for Regenerative Electronic AC Load

, M.Sc. Thesis Sharif University of Technology Akhlaghi, Sadegh (Author) ; Zolghadri, MohammadReza (Supervisor)

Abstract

Generally, virtual loads is used to test all AC power and energy meters and are usually passive. To prevent possible damage of this heat and to control the temperature, cooling blowers are used which increases the volume and weight. So, recycling the power delivered from the grid causes a small amount of power to be converted to heat in proportion to the load efficiency. The purpose of this study is design, predictive controller model for programmable electronic regenerative AC load. The structure used is a back-to-back converter consisting of an AC-DC converter and a DC-AC converter, which according to existence of capacitance between these two structures, two converters can be controlled...

Modeling, control and voltage unbalance compensation in a four-switch rectifier with input power factor correction

, Article PEDSTC 2013 - 4th Annual International Power Electronics, Drive Systems and Technologies Conference ; 2013 , Pages 148-152 ; 9781467344845 (ISBN) Ouni, S ; Shahbazi, M ; Zolghadri, M ; Sharif University of Technology

2013

Abstract

In this paper, a small signal model is proposed for four-switch rectifier with input power factor correction. The required transfer functions are determined and calculated for a typical rectifier. This model is used to design an appropriate controller with defined characteristic to improve the rectifier performance. Another controller is used to compensate capacitors dc voltage difference. The system is simulated in Simulink and the results are provided. These results confirm the accuracy of the developed model, and also the effectiveness of the proposed controllers

A modulation method for leakage current reduction in a three-phase grid-tie quasi-Z-source inverter

, Article IEEE Transactions on Power Electronics ; 2018 ; 08858993 (ISSN) Noroozi, N ; Yaghoubi, M ; Zolghadri, M ; Sharif University of Technology

Institute of Electrical and Electronics Engineers Inc 2018

Abstract

The leakage current originated from the fluctuations of the common-mode voltage (CMV) is an issue in a transformerless grid-connected photovoltaic (PV) system. In this paper, a modified space vector modulation based on the Fourier transform analysis is proposed to reduce the leakage current in a three-phase quasi-Z-source inverter (qZSI). The CMV harmonic content in a qZSI contains low and high-frequency harmonics which cause safety and EMI problems respectively. By implementing the proposed modulation in a three-phase qZSI, the low-frequency harmonics of the CMV are mainly reduced. The distribution of the high-frequency harmonics is also modified in a way they can be simply filtered....

A three-winding coupled-inductor high step-up boost converter with an active-clamp circuit

, Article 12th Power Electronics, Drive Systems, and Technologies Conference, PEDSTC 2021, 2 February 2021 through 4 February 2021 ; 2021 ; 9780738111971 (ISBN) Amani, D ; Beiranvand, R ; Zolghadri, M ; Sharif University of Technology

Institute of Electrical and Electronics Engineers Inc 2021

Abstract

A new high step-up boost converter with an active clamp circuit to eliminate voltage spike caused by leakage inductor is introduced in this paper. The introduced power converter has a high voltage gain for variable input voltage from 48V to 80V. Since both main and auxiliary switches turn on with zero voltage switching (ZVS) and all the diodes turn off under zero current switching (ZCS) condition, switching losses and EMI noises are strongly degraded. Therefore, the converter's efficiency is improved significantly. Simulation results show a 96.4% peak efficiency and 95.4% average efficiency. The proposed topology is suitable for low-input-voltage and low-output power applications such as...

A new high step-up interleaved LLC converter

, Article 12th Power Electronics, Drive Systems, and Technologies Conference, PEDSTC 2021, 2 February 2021 through 4 February 2021 ; 2021 ; 9780738111971 (ISBN) Amani, D ; Beiranvand, R ; Zolghadri, M ; Sharif University of Technology

Institute of Electrical and Electronics Engineers Inc 2021

Abstract

In this study, a new LLC resonant converter for high-voltage high-power applications is introduced. The introduced power converter is a two-phase interleaved full-bridge based that uses a transformer with secondary and tertiary windings to obtain higher output voltage. Zero voltage switching (ZVS) at MOSFETs turn on and zero current switching (ZCS) for all the output diodes at turn off are achieved for a wide range of input voltage (100 V-200 V) and output power (200 W-1500 W) variations. Simulation results show a 95% peak efficiency. © 2021 IEEE

Energy Savings in the Urban Electrified Railway using Onboard Storage Systems Energy Savings in the Urban Electrified Railway Using Onboard Storage Systems

, M.Sc. Thesis Sharif University of Technology Hanifi, Mahmood (Author) ; Zolghadri, Mohammad Reza (Supervisor)

Abstract

Given the high rate of energy dissipation in electric urban rail lines, methods of saving energy in these systems have become a topic of interest. The use of energy saving equipment to save the energy wasted in braking (Because of the diode rectifier, thermal energy is usually wasted and is not reversible) can play an important role in reducing the energy loss. The role of energy storage equipment, from other aspects such as voltage regulation and increasing the system reliability is also remarkable. In this thesis, the various possible methods for saving energy in the Metro system are expressed.
The various types of storage devices with increased reuse of braking energy which is the...

Efficiency Improvement of a Three-Phase Telecom Rectifier with Single-Stage Structure and Power Factor Correction

, M.Sc. Thesis Sharif University of Technology Noroozi, Negar (Author) ; Zolghadri, Mohammad Reza (Supervisor)

Abstract

The objective of this project is to design and control and optimize a single-stage three-phase three-switch unity power factor telecom rectifier. For this purpose, the topology of three-phase three-switch converter has been investigated for both isolated and un-isolated converters. Following a comprehensive investigation on the converter structure, the power dissipation factors have been detected and the quantity of the power dissipation has been calculated by analytical methods and it confirmed by simulation results. To avoid extra power losses some novel soft-switched structures for three-phase three-switched converters have been introduced. the proper operation of the soft-switched...

Efficiency Improvement of a PWM Rectifier Using Soft Switching and Redesign of the Modified Converter

, M.Sc. Thesis Sharif University of Technology Haghi, Rasool (Author) ; Zolghadri, Mohammad Reza (Supervisor)

Abstract

In this project, the Line-Modulated Fixed Off-Time method is used as the current control strategy for a Power Factor Corrector (PFC) pre-regulator. A zero voltage switching PWM (ZVS-PWM) auxiliary circuit is configured to perform ZVS in the switches. To reduce conduction losses, the rectifier circuit and the PFC are combined to create bridgeless PFC and a new zero-voltage-switching is introduced for reduse switching loss. Soft commutation of the main switch with zero voltage is achieved without additional current stress. When main switch is turned off ,the voltage across the switch rises very slowly. when the current of the switch decays to zero the voltage across the switch is very low.A...

Design and Simulation Hybrid Energy Storage Systems for Electric Urban Rail Transport Systems

, M.Sc. Thesis Sharif University of Technology Heydari, Mohammad (Author) ; Zolghadri, Mohammad Reza (Supervisor)

Abstract

In urban rail transport systems such as subway, Trains are constantly accelerate and brake, so the braking system is of great importance in energy consumption and constitute about 30 to 40 percent of total energy consumption trains, thus retrieval braking energy will lead to significant savings in urban rail transport systems. In this paper, in the beginning, different storage equipments for storage braking energy have been studied and compared and finally Supercapacitors due to technical and economic features have been selected for the storge of equipment. These systems can be implemented in both stationary and onboard. For precise evaluation and select the appropriate storage system, by...

Post Fault Vector Control of CHB Driven Induction Motor

, M.Sc. Thesis Sharif University of Technology Fathi, Manochehr (Author) ; Zolghadri, Mohammad Reza (Supervisor)

Abstract

Multilevel converters are considered recently as one of the industrial solutions for high-power and power quality demanding applications. Casacade H-Bridge (CHB) converter is one of the well known topologies among multilevel converters. CHB converter is characterized by its high modularity allowing its power to be easily increased. Modularity also allows any faulty cell to be isolated, so the load can be fed by the remaining operative cells, which leads to an unbalanced output voltage of the CHB converter. To avoid the unbalanced operation, recently a solution based on modifying the phase and the magnitude of the voltage refereces has been proposed. This thesis presents a method to control...

Design and Implementation of FPGA Based Real Time Simulator for Power Electronic Converters

, M.Sc. Thesis Sharif University of Technology Rezayati, Mohsen (Author) ; Zolghadri, Mohammad Reza (Supervisor)

Abstract

Real-time Simulator plays an important role in the test of power electronic converters. Using of this simulators and Hardware-in-the-loop tests, cost and time of experiments will redused, furthermore those experiments which are not operative on the real system, can be achived. However, the accuracy of the used model in simulation as well as fast and easy programming of these simulators is very important. Therefore in this thesis, design and implementation of real-time simulator for power electronic converters have been discussed that in addition to high accuracy of the simulation, implementation of the several tests will be easy. As regards the power electronic switch is the most important...

High Efficiency Off-Line Light-Emitting Diode (LED) Driver with Long Lifetime

, M.Sc. Thesis Sharif University of Technology Valipour, Hamed (Author) ; Zolghadri, Mohammad Reza (Supervisor)

Abstract

Recent developments in improving lighting efficiency and cost reduction of LED’s have caused them to be a suitable alternative for the current lighting systems. In this thesis a novel off-line structure is proposed to drive LED’s. The proposed circuit has a high power factor and high efficiency and a long lifetime. To increase the life time of the converter, the proposed circuit doesn’t use any electrolytic capacitors in the power stage. The proposed circuit consists of a transition mode (TM) flyback converter in order to have power factor correction (PFC), a buck converter is added to the third winding of the flyback transformer in order to create two paths for the electrical power. DC...