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    Synthesis of β- Amino Carbonyl Compounds in Solvent-free Condition in the Presence of SiCl4 And Synthesis of Benzothiazole Derivatives

    , M.Sc. Thesis Sharif University of Technology Baghi, Roya (Author) ; Mahmoodi Hashemi, Mohammad (Supervisor) ; Azizi, Najmeddin (Supervisor)
    Abstract
    SiCl4 catalyzed Michael addition reaction of aliphatic and aromatic amines with different α,β- unsaturated compounds and one-pot three component Mannich reaction under solvent-free condition were investigated. β-amino carbonyl compound were synthesized in high yield in short reaction time. Furthermore, in the Mannich reaction good yield and excellent stereoselectivity were observed. In addition, the synthesis of 2-substituted benzothiazoles from aromatic aldehydes and 2 aminothiophenol in moderate to excellent yields in water in the presence of PTSA catalyst (10 mol%). This method provides a simple and efficient protocol in terms of mild reaction conditions, clean reaction profiles, small...