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Synthesis of Pyrimidine Derivatives Fused to Pyrazol Ring Using Iodine-Catalyzed Two Component Reaction & Synthesis and Application of Magnetic Nickel Ferrite Nanoparticles in the C-N Bond Formation
, M.Sc. Thesis Sharif University of Technology ; Matloubi Moghadam, Firouz (Supervisor)
Abstract
The fused pyrimidine rings have many biological applications such as antibacterial, antiviral, antitumor and anti-inflammation activity. Therefore, their synthesis has attracted many attentions. In this thesis, the synthesis of fused pyrazolopyrimidine rings through two component reaction catalyzed by iodine was investigated. In this reaction, iodine is used to active the imine bond. Low toxicity, availability, low cost and stability to air are some benefits of iodine as a Lewis acid leading to widespread application of I2 in many different organic transformation. Mild reaction conditions, high yields and lower reaction times are among the main advantage of these reactions.
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