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Production of Biocellulose Nanofibers by Gluconacetobacter and Evaluation of the Release of the Azithromycin Antibiotic Loaded on It in a Simulated Gastric Fluid
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor)
Abstract
Bacterial cellulose is a kind of cellulose with high purity and Crystallization, which is mainly produced by gram-negative bacteria in aqueous media containing a sugar source.Cellulose produced by this method is in the form of nanofibers and one of its considerable aspects, nowadays, is that this kind of cellulose is used as a drug carrier system for treating various diseases. Azithromycin is used as an antibiotic for the treatment of a wide range of bacterial infections. In this study, cellulose nanofibers were synthesized by gluconacetobacter and its surface was modified using 0.5, 1, and 1.5 mg/ml carboxymethylcellulose solution in sodium acetate buffer. Then, by stabilizing azithromycin...
A Gold Nanoparticle-based Colorimetric Sensor Array for Detection and Discrimination of Antibiotics in Groundwater
, M.Sc. Thesis Sharif University of Technology ; Hormozinezhad, Reza (Supervisor)
Abstract
Antibiotics (ABs) have been regarded as powerful medications to treat or prevent bacterial infections. The antibiotic resistance though, is one of daunting challenges of our time which has been attributed to the overuse of these drugs and usage of antibiotic-contaminated food resources. Developing rapid and visual detection methods capable of simultaneously monitoring Abs is highly desired due to their harmful effects on human health. In the present study, we have designed a colorimetric sensor array consisting of two types of gold nanoparticles (i.e., Citrate-capped gold nanoparticles (Cit-AuNPs) and Borohydride-capped gold nanoparticles (BH4-AuNPs) for the discrimination and determination...