Sharif Digital Repository

In recent years, many efforts have been made in tissue engineering and new methods for the treatment of cartilage damage, with an emphasis on their non-invasive and less aggressive nature. Meanwhile, injectable and in situ forming hydrogels have been considered as a less invasive nature. On the other hand, lack of enough mechanical properties in these hydrogels is one of their main problem. In this study, gelatin and alginate was used to fabricate hydrogel as interpenetrating network (IPN) hydrogel and silica nano particles were also used to increase mechanical properties in the fabricating of hydrogels. Gelatin is also combined with dopamine in order to induce bio adhesive properties of... 

Corneal perforations are one of the most widespread illnesses which are associated with severe pains and vision loss. Eyes with corneal perforations must be treated immediately in order to preserve its morphology and prohibit secondary complications. Opthalmologist usually apply cyanoacrylate and fibrin glues for filling and sealing incisions, but they have several drawbacks besides their advantages. Cyanoacrylates which are unabsorbable remains as a foreign body in the patient’s eyes and will cause annoyment. Fibrin glues that are attained from ibrinogen and thrombin, can transfer blood diseases. Therefore, fabricating a bioadhesive with high biocompatibility, adhesion and...