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biothiols
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Design of Nature-Inspired Multicolor Sensor for Detection and Discrimination of Biothiols based on Anti-Etching on Gold Nanorods
, M.Sc. Thesis Sharif University of Technology ; Hormozinezhad, Mohammad Reza (Supervisor)
Abstract
Biological thiols are crucial substances that play an essential role in several biological processes and activities in the body. Hence, the fluctuation of their concentrations can be used as a diagnostic sign for numerous disorders. In contrast, the ratio of these thiols to their disulfide form within the cell is useful as an indicator for determining cytotoxicity. Hence, it is crucial for develop a simple yet efficient analytical technique for quickly recognizing and determining them. The purpose of this study is to develop a plasmonic colorimetric sensor by utilizing gold nanorods (AuNRs). This sensor aims to accurately measure and distinguish between cysteine (CYS) and glutathione (GSH),...
Design of Optical Sensor Arrays Using Plasmonic and Fluorescent Nanoprobes for the Detection of Antidepressants, Biothiols, and Discrimination of the Enantiomers of Tryptophan, Histidine, and Arginine
, Ph.D. Dissertation Sharif University of Technology ; Hormozinezhad, Mohammad Reza (Supervisor)
Abstract
In the first part of this research, a single-component colorimetric sensor array based on the aggregation of AuNPs has been designed for the quantification and classification of antidepressant drugs (fluvoxamine (Flu), nortriptyline (Nor), citalopram (Cit), alprazolam (Alp), diazpam (Dia), sertraline (Ser), zolpidem (Zol), and imipramine (Imi)). Tuning the pH and ionic strength enabled the single-component probe to interact with the target analytes through different binding modes, providing the required cross-reactivity. To generate the array, a single AuNP was embedded into six experimental conditions: three different buffers (acidic, neutral and basic) each at two concentration levels (1mM...