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Design and Construction of PCL Nanofiber Scaffold for Bladder Tissue Engineering
, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheyla (Supervisor) ; Mashayekhan, Shohreh (Co-Advisor)
Abstract
In this project, a novel system of bioactive electrospun scaffold for bladder tissue engineering , has been investigated to control in vitro cell differentiation, and utilize in in vivo vascularization and tissue formation. This method doesn’t have custom bioactive scaffolds problems such as, protein instability, technical complexity and, difficulties in accurate kinetics prediction. First of all, protein loaded chitosan nanoparticles based on ionic gelation interaction between chitosan and Sodium tripolyphosphate were prepared. Maximum protein loading efficiency (80% for BSA & 99% for TGF-beta1) in chitosan nanoparticles was obtained at mean diameter of 51nm. Moreover polycaprolactone...
Effect of Urease on the Motion of Janus Micromotors Based on Black Titanium Dioxide
, M.Sc. Thesis Sharif University of Technology ; Madaah Hosseini, Hamid Reza (Supervisor)
Abstract
The bladder is one of the most important internal organs of human that improper functioning of this organ causes various diseases such as bladder exstrophy, bladder syndrome, bladder cancer and bladder infection. The main challenge in treating these diseases is the presence of a mucous layer consisting of glycosaminoglysis (GAG) in the bladder wall that prevents drugs from reaching the surface of the bladder. Hence, drug delivery through the mucosal layer is not easy, Hence, urease micro/nano carriers have recently been considered for the treatment of bladder diseases. In this study, new janus micromotors based on black titanium oxide with asymmetric urease catalytic coating were synthesized...