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Sol-Gel Preparation and Study of Bio-Composite Scaffold Containing Chitosan-Gelatin/ Nano-Hydroxyapatite for Bone Tissue Engineering
, M.Sc. Thesis Sharif University of Technology ; Mohammadi, Mohammad Reza (Supervisor)
Abstract
In present work, hydroxyapatite nano-rods are synthesized using a simple sol-gel method with calcium nitrate and potassium dihydrogenphosphate as calcium and phosphorus precursors respectively and ammonia was used for adjusting the pH=9. To obtain rod shape hydroxyapaite powder, multi wall carbon nanotubes were added to the solution, nHA powder was calcinated at 60 and 450 ℃. In second step, chitosan-gelatin/nanoHA solution were prepared by blending chitosan and gelatin in different concentrations with nanoHA powder, then the solution was freeze dried to maintain a composite scaffold. The prepared HA powder and bio-composite scaffold were characterized by X-ray diffraction (XRD), field...
Optimization of Load Distribution at the Bone-Implant Interface in Porous Coated Implants ''A Micromechanical Study Using FEM'
, M.Sc. Thesis Sharif University of Technology ; Katoozian, Hamid Reza (Supervisor) ; Ahmadian, Mohammad Reza (Supervisor) ; Zohoor, Hassan (Supervisor)
Abstract
Loosening and gap opening at the bone-implant interface depends on several physiological and mechanical factors such as bone remodeling, stress concentration, and variation in load transfer pathway. Since fracture of orthopedic material at the interface is one of the major failure mode of total joint implants, this study focused on the micromechanical behavior of the interface. Using a two-dimensional FE model, with pure compressive, tensile, and shearing forces applied on bone or cement, ratio of the stress at the interface to the applied stress has been calculated. Stress distribution was considered as a function of porosity,angle of bead contact to surface, as well as size of bead for two...