Sharif Digital Repository

In the last decade, the application of organ-on-chip systems to investigate the effectiveness and side effects of various drugs, modele diseases for different tissues has become noticed a lot because these systems are a promising approach to eliminate animal tests and clinical studies on different people. Current conventional methods for drug testing are expensive, time-consuming, and sometimes unreliable. Various organ-on-a-chip systems have been fabricated in order to mimic the conditions of different native tissues in the human body, but only the blood vessel has been considered in most of them while besides blood vessels, as a source to nourish cells, there are lymph vessels as a sink in... 

Cardiovascular diseases have been one of the leading causes of mortality in recent years. Therefore, the design and development of drugs for the prevention and treatment of heart diseases has always been one of the key strategies to combat these conditions. Traditional methods such as two-dimensional (2D) cell cultures and animal models are limited in their ability to accurately replicate the real structure of the human heart. In this regard, advancements in in vitro models aimed at better simulating physiological conditions have led to the development of heart-on-a-chip technology. In this study, by designing and fabricating a heart-on-a-chip model, the effect of the anticancer...