Sharif Digital Repository

Breast Cancer is considered one of the most common cancers among Iranian women. Every year, seven thousands women start suffering from this disease. Since 70 percent of this patients live over 5 years, after this disease starts, there are 70 thousands women who are suffering from the cancer. The average age of getting the disease in Iran is 5 years lower than that of the global level. Studies show that compound containing Chromene and Carboxamides are appropriate candidates for preventing breast cancer. One of the most important fields of researches in Chemistry and Bio-Chemistry is QSAR which is used to relate the structure of molecules to their activities. In this study, molecular... 

An efficient one-pot procedure is described for the synthesis of derivatives of 3,4-Dihydrochromen-2-ones under solvent-free and metal-free conditions via a pseudo-four-component domino reaction of acetic anhydride, aryl aldehydes, glycine-based dithiocarbamates, and phenols/naphthols. All products were made under green strategy with high yields