Sharif Digital Repository

The cornea is a transparent, avascular, multilayer, connective tissue. When the erosion process of these cells occur, where natural and quick restoration is expected, corneal disorders begin. Regeneration of corneal tissue, using a biocompatible method is a great point of interest. Nowadays, scaffold based on amniotic membrane is used as a basement membrane in the regeneration of corneal tissue. Lots of researches focused on using auto graft scaffold to decrease the inflammation and infection of an allografts and synthetic scaffolds, while overcoming amniotic membrane’s weak mechanical properties. The aim of this survey is to construct an appropriate scaffold from patient’s own blood to... 

Corneal diseases are one of the most common causes of blindness worldwide. The most common way to treat these diseases is to replace the damaged cornea with the donor cornea by corneal transplant. But limitations such as donor tissue deficiency, the risk of disease transmission and transplant rejection have made treatment of these diseases very difficult. A cornea made by tissue engineering can be used as a suitable alternative because of the limitations mentioned for corneal transplantation with donated tissue. At the same time, similarity of the scaffold to normal corneal tissue, both in terms of matrial and structural properties, is essential for proper repair of this scaffold by cells...