Sharif Digital Repository

The “hypothalamus-pituitary-adrenal” axis is one of the most important axes of the human body, and cortisol is one of its key products, which plays an essential role in the immune system, stress management, and many diseases. Appropriate modeling and simulation of this axis can help us to understand how the body reacts to stress and inflammation, to examine relevant diseases, and how drugs affect the body. In this study, by combining an axial model of the hypothalamic-pituitary-adrenal axis with a model of adrenal cells, a bi-level model including several time delays has been developed that can predict the effect of stress on this axis. Some parameters of the model have been modified through...