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cyclopentadiene
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Synthesis of Pd-based Magnetic Nanocatalyst and its Application on C-F Activation in Coupling Reactions, Using Sm for Cyanation Reacion and Diastereoselective Synthesis of Novel Hit Compounds and Their Pharmacological Evaluation
, M.Sc. Thesis Sharif University of Technology ; Matloubi Moghaddam, Firouz (Supervisor)
Abstract
Formation of C-C and C-hetero atom bonds in coupling reactions is among the most important organic chemistry reactions, which is useful for achieving the complex molecules from simple ones. The goal of this thesis, was using the organometallic and also metal free methods in coupling reactions and getting the advantage of them in the synthesis of novel hit compounds. In this way, some novel reactions were designed and some novel catalysts were synthesised and identified. Finally, computational quantum chemistry and computational drug design were used as powerful tools for supporting the reaction mechanism, electronic and structural studies and pharmacological evaluation. C-X bond activation...