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    Study of the Baby Boom in Iran

    , M.Sc. Thesis Sharif University of Technology Malvandy, Mina (Author) ; Rahmati, Mohammad Hossein (Supervisor) ; Vesal, Mohammad (Supervisor)
    Abstract
    This paper studies the impact of the revolution on a rise in the rate of marriage and baby boom in the late 1980’s. The key factors that incentivize doing research in this area are manifold—three of which, however, are of great importance: first, the answer to this research question is still a matter of debate; Second, the number of studies in the case of Iran is insufficient; Third, the well-known theoretical models developed in non-Iranian cases are not compatible with the case of Iran. Our research hypothesis is based on the fact that during a period before and after the revolution, people were tremendously involved in the unstable political situation and, therefore no matter what... 

    Inferring the Demographic History of Iranian Populations from Whole Exome Sequencing Data

    , M.Sc. Thesis Sharif University of Technology Heidari, Jalal (Author) ; Motahari, Abolfazl (Supervisor) ; Khalaj, Babak (Supervisor)
    Abstract
    One of the cornerstones of population genetics is finding ancestral relations between people of a population. Mutations and recombinations are two major signals that can be exploited to infer the population ancestral relationships. Next Generation Sequencing (NGS) has paved the way for achieving this endeavor by providing massive data including single nucleotide polymorphisms, insertions, and deletions as well as structural variations between individuals. In this thesis, the goal is to infer the ancestral structure of a given gene from thousands of NGS datasets. We also attempt to decode times of important events including mutations and recombinations. To this end, we first split a gene into... 

    Inferring Relation between World and Iranian Populations from Microarray Data

    , M.Sc. Thesis Sharif University of Technology Saberi, Sasan (Author) ; Hossein Khalaj, Babak (Supervisor) ; Motahhari, Abolfazl (Supervisor)
    Abstract
    One of the branches of genetic studies is population genetics. Each population has its own characteristics due to its evolutionary history, cultural characteristics and geography, which distinguish it from other populations. Scientific and technological advances in recent decades have led to the production of new generation sequencing machines and the creation of large genetic data. These data contain important genetic information and answers to many questions about the origin of humans, the history of populations and their evolutionary process. More and better understanding of the human genome and the distance between populations can help to better understand biological mechanisms and deal...