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    Dendrimers and Other Nanostructures by the Approach of Graph Theory

    , M.Sc. Thesis Sharif University of Technology Mohammad Hasani, Behtash (Author) ; Mahmoodian, Ebadollah (Supervisor)
    In this thesis, we study the application of graph theory in chemistry. Such as, molecular graphs, modeling, algorithms, topologicalindicesandsoon. Themaingoalinthisresearchis collecting problems in chemistry which have mathematical models, specially in graph theory. Also we study the methods applied to them by considering the problems in chemistry with mathematical approach. In particular case, dendrimers and other structures of chemistry have been attributed to some graphs, where by studying their graphical parameters, like connectivity, independent sets, perfect matchings, isomorphism and topological indices and other parameters, we obtain some results in chemistry  

    Design of Drug Nanocarriers Based on Mesoporous Silica Nanoparticles Coated with Smart Polymers

    , Ph.D. Dissertation Sharif University of Technology Mazaheri Tehrani, Zahra (Author) ; Pourjavadi, Ali (Supervisor)
    Mesoporous silica nanoparticles have broad application in drud delivery systems due to their porous structure, functionalization, biocompatibility, high surface area and pore volume. Neverthless, pure mesoporous silica nanoparticles without functionality were not smart material and could not release drug in triggered and controlled manner. For this reason, using smart polymeric coating would be considered. Polymer shells also provide colloidal stability, improved blood circulation lifetime and reduced toxicity which are crucial for efficient in vivo drug delivery. Inflammatory and tumor tissue have low pH and high temperature as compared to health tissue. Therefore, using pH and... 

    Nanomagnetic Polyamidoamine Dendrimer as A Novel Sorbent for Solid Phase Microextraction of Chlorophenols from Aquatic Media

    , M.Sc. Thesis Sharif University of Technology Manouchehri, Mahshid (Author) ; Bagheri, Habib (Supervisor)
    In this study, ananomagnetic polyamidoamine (PAMAM) dendrimer was synthesized as a novel SPME fiber coating and implemented to the determination of traces of chlorophenols in water samples. The synthesized magnetic PAMAM shows to have many polar groups with an enhanced internal porosity which is promising to be used as an efficient extracting medium. With this purpose, a thin stainless steel wire was coated by the network of dendritic PAMAM polymer through electrolysis and chemical reactions. The synthesized fiber is physical stable since it was chemically bonded to the substrate. Extraction efficiency of new coating was investigated by headspace SPME of chlorophenols from aqueous samples... 

    Synthesis and Characterization of Properties of Hybrid Nanoparticles of Gold-graphene

    , M.Sc. Thesis Sharif University of Technology Akhoondi, Soheila (Author) ; Simchi, Abdolreza (Supervisor)
    In recent years utilization of quantum dots for stem cells detection and clean energy production has received intensive attention. Graphene and its derivatives have been widely studied because of their effectiveness on electronical and optoelectronical devices, chemical sensors, nanocomposites, and energy storage. By use of metal nanoparticles, such as AuNPs, we can develop properties of graphene, and control them via shifting the absorption peak wavelength and increasing its biocompatibility. In this research, hybrid nanoparticles of gold-graphene as core-shell and conjugated by polymeric linkers containing amine or thiol functions are synthesized. Our purpose is stabilization the... 

    Synthesis of Magnetic Nanocarriers Based on Coating of Fe3O4 with Modified Biodegradable Polysaccharides by pH Sensitive Agents for Targeted Release of Anticancer Drug Doxorubicin

    , M.Sc. Thesis Sharif University of Technology Amin, Shiva Sadat (Author) ; Pourjavadi, Ali (Supervisor)
    One of the major problems in cancer treatment is the side effects of the drugs. Nowadays, scientists are developing smart nanocarriers which used for diagnosis and delivering drugs in order to circulate through blood vessels, pass the immune system, attach to cancer cells and kill them without any side effects. In the first research of this thesis, magnetic nanoparticles were coated by modified alginate and used as smart nanocarriers. Magnetic nanocarrier were sysnthesized based on hydrophobic coating of oleic acid and hydrazine oleate-modified alginate shell. The resulting carrier is pH-sensitive and the alginate shell removes in the low pH medium. DOX was placed between hydrophobic chains....