Sharif Digital Repository

In the first section, a novel and efficient multicomponent reaction for the synthesis of polysubstituted pyrrolidine derivatives is described under catalyst-free conditions using unltrasonic irradiation. The reactions were performed via a one-pot four-component condensation of secondary amines, carbon disulfide, isocyanides, and gem-dicyano olefins at room temperature to afford polysubstituted pyrrolidines diastereoselectively in 56-96% yields. This is the first report of Mumm-type rearrangement with dithiocarbamates followed by intramolecular cyclization which lead to the preparation of the key structure of pyrrolidine.In the second section, an efficient and unprecedented green protocol... 

An efficient and facile one-pot, multi-component reaction for the regio- and diastereoselective synthesis of novel dispirocyclopentanebisoxindoles has been reported by a reaction between phenyl-2- (triphenylphosphoranylidene)ethanone and isatin derivatives. The great advantages of this synthetic protocol are the minimal reaction steps, short reaction time, and operational simplicity. In consequence, a variety of new dispirocyclopentanebisoxindole derivatives with potential medicinal applications were synthesized through one-pot and multi-component reaction in high to excellent yields