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Enhancing and Normalizing DNA Microarray Data Using RNA-seq Dataset
,
M.Sc. Thesis
Sharif University of Technology
;
Motahari, Abolfazl
(Supervisor)
;
Beigy, Hamid
($item.subfieldsMap.e)
Abstract
Nowadays, many progresses in biology and medicine such as diagnosis of diseases and drug discoveries depend heavily on analyzing biological datasets collected from advanced machines. DNA Microarrays are amongst such machines applicable in measuring the expressions levels of thousand of genes and genotyping of a set of single nucleotide polymorphic sites to name a few. Compared to the more advanced Next Generation Sequencing (NGS) technology, the microarray platform produces lower quality of datasets. However, there has been tones of efforts to produce, process, and curate datasets from microarrays based on well designed protocols for sample preparation, hybridization, image processing, and...