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Fabrication and Characterition of Flour Bearing Fibroin/ Nano-TiO2 Biodegradable Nanocomposite for Bone Tissue Engineering
, Ph.D. Dissertation Sharif University of Technology ; Maddah Hosseini, Hamid Reza (Supervisor)
Abstract
It is known that Fluoride ions strongly affect bone mineralization and formation. In the present study, the engineered bone tissue scaffolds are fabricated using silk fibroin (SF) and flouridated TiO2 nanoparticles. TiO2 nanoparticles are modified by fluoride ions, and different levels (0, 5, 10, 15 and 20 wt.%) of the fluoridated TiO2 nanoparticles (TiO2-F) were subsequently added to the SF matrix through phase separation method to prepare silk fibroin/flouridated TiO2 nanocomposite scaffolds (SF/TiO2-F). Phase structure, functinal groups, morphology and mechanical properties of the obtained scaffolds were evaluated by X-ray difraction method (XRD), Fourier transform infrared spectroscopy...
Design and Fabrication of Biodegradable Polymeric Scaffold with nano-Bioglass for Osteoblast cell Growth
, M.Sc. Thesis Sharif University of Technology ; Vossoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Supervisor) ; Tamjid Shabesteri, Elnaz (Co-Advisor)
Abstract
Treatment of critical-size bone defects caused by sport injuries, accidents, trauma, infection, and osteoporosis remains a major clinical challenge. In order to repair or regenerate large bone defects, bioactive three-dimensional scaffolds play a key role due to their multilevel porous structure, high surface area, enhanced mass transport and diffusion. Many studies reported that macropore diameters greater than 500 µm can lead to vascularized bone tissue. In this study, a hierarchically porous composite scaffold was prepared. Hierarchically porous silk fibroin- bioactive glass composite and fibroin scaffold were fabricated with controlled architecture and interconnected structure with...