Sharif Digital Repository

In recent years, cancer is the second leading cause of human death. Cancer treatment is based on surgery, chemotherapy and radiation therapy. Choice of treatment method depends on the degree of progression and type of cancer. However, the goal is destruction of cancer cells and minimal harmful side effects on healthy cells. In this thesis two types of polysaccharide-anticancer drug conjugate were prepared and evaluated for radiation therapy and chemotherapy; chitosan- and DTPA modified chitosan – Gallium 66 conjugates for radiation therapy and nano diacid starch –cisplatin conjugate for chemotherapy. Chitosan –gallium 66 conjugate was prepared in radiochemical purity higher than 99% at...