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    Electrodeposition of Pt nanostructures and its Application as Glucose Sensor

    , Ph.D. Dissertation Sharif University of Technology Mahshid, Sahar Sadat (Author) ; Dolati, Abolghasem (Supervisor) ; Ghorbani, Mohammad (Supervisor)
    The present work describes sensing application of modified Pt nanostructures towards detection of glucose. Modified Pt nanostructured electrodes were prepared using electrodeposition method such as chronoampermetry and potentiostatic pulse methods. The electrodeposition of Pt nanostructures was first studied by voltammetry and amperommetry techniques and then potentiostatic pulse method has been used to produce the alloyed structures of platinum. In this regard, the first electrode was proposed based on alloyed Pt/Ni nanowire arrays (NWAs) for the non-enzymatic detection of glucose. The Pt/Ni NWAs were prepared by pulse electrodeposition of Pt and Ni within a nano-pore polycarbonate (PC)... 

    Theoretical Investigation of Hydrogen Bonding Effects on Interaction of Metal Nanoclusters with Biomolecules & Acidity Enhancement of Alcohols

    , Ph.D. Dissertation Sharif University of Technology Ali Akbar Tehrani, Zahra (Author) ; Fattahi, Alireza (Supervisor) ; Mahmoodi Hashemi, Mohammad (Supervisor) ; Jamshidi, Zahra (Co-Advisor)
    This thesis is divided into three parts: In part I, conformational properties of neutral, anionic, cationic and zwitterionic forms of glutathione tripeptide were investigated by means of DFT-B3LYP method with 6-31+G (d,p) basis set. Results show that glutathione is a very flexible molecule and its conformational energy landscape is strongly influenced by forming intramolecular hydrogen bond and its charge. Conformation of each amino acid in glutathione tripeptide depends on its orientation within the peptide sequence in addition to the conformation of other amino acids within the chain. Investigation of intramolecular hydrogen bonds in these conformers by means of AIM analysis demonstrates... 

    Study of CNT/ZnO/PANI Nanocomposite Biosensors

    , M.Sc. Thesis Sharif University of Technology Yazdanbakhsh Sorkhabi, Khashayar (Author) ; Dolati, Abolghasem (Supervisor)
    For application as a biosensor electrode, Aligned Carbon Nanotubes (CNTs) were produced on Stainless Steel 304 substrate by optimizing the CVD method. For better performance, Zinc Oxide (ZnO) nanoparticles were coated on CNTs, using electrochemical deposition method at room temperature and process variables were optimized to acquire discrete particles with a narrow distribution. After that, Polyaniline, which is a conductive polymer, was electropolymerized on CNT/ZnO composite to further improve the electrocatalytic abilities of the electrode. The produced electrode was then used to detect glucose by Cyclic Voltammetry and Amperometry methods. This electrode shows a linear relationship... 

    Fabrication of Hybrid Graphene/Metal Electrodes for Biosensor Applications

    , M.Sc. Thesis Sharif University of Technology Mohammadzadeh, Amirmahdi (Author) ; Simchi, Abdolreza (Supervisor)
    Electrochemical sensing of glucose has received paramount attention in recent years, particularly, the non-enzymatic glucose sensing is one of the trends in the whole biosensing world. In this research, synthesis and evaluation of a hybrid structure of vertical oriented nickel nanorod-reduced graphene oxide sheets as a non-enzymatic glucose sensor were performed. The 3D array of nickel nanorods was synthesized by electrodeposition of nickel sulfate electrolyte in track-etched polycarbonate template with 100 nm pore size and 6-10 μm thickness. The electrodeposition performed in various conditions, and the best result was achieved by application of potential of 3 V for 60 minutes. The shiny... 

    The Immobilization of Saccharides onto the Magnetic Nanoparticles of Fe3O4 and its Application as an Efficient Ligand for Support and Stabilization of Metallic Cations in Organic Reactions such as Synthesis of 1, 2, 3-Triazoles & 2-Substituted Benzoxazoles

    , M.Sc. Thesis Sharif University of Technology Kalhor, Sepideh (Author) ; Matlubi Moghaddam، Firouz (Supervisor)
    One of the most challengeable topic in the field of green chemistry is the synthesis of organic structure in water. In this project immobilized glucose on Fe3O4 was prepared as a nano heterogeneous dispersive catalyst in water. The catalyst was fully characterized by FT-IR, TGA, CHN, SEM, EDX and atomic absorption spectroscopy. The synthesized catalyst was used in the synthesis of different derivatives of 1,2,3-triazole via one-pot three component reaction of alkynes, alkyl halides, sodium azides; And to the best of our knowledge this novel catalyst coin sides to the principles of green chemistry. This nano catalyst can be recycled and reused for several runs without significant loss of its... 

    PEC Sensing of Glucose Using one Dimensional TiO2 Nanostructure Modified by Two Dimensional Material

    , M.Sc. Thesis Sharif University of Technology Saadati, Ali Akbar (Author) ; Naseri, Naimeh (Supervisor)
    In this study, one dimensional titanium dioxide nanostructures including nanotube and nanowire were synthesized by anodization and hydrothermal methods respectively and were used for PEC glucose sensing. Meanwhile various length of nanotubes was investigated toward glucose sensing. Finally, nanotubes with the length of 2.7 µm were selected as the optimum sample. Finally, to improve sensitivity toward glucose, TiO2 nanotubes were modified by graphene oxide nanosheets which caused several percent increase in PEC sensing performances. In the next stage branched TiO2 nanowires were grew on FTO substrate in various conditions. In spite of acceptable reproducibility of this structure,... 

    Design of a Microfluidic System for Continuous Glucose Measurement, as well as Fabricating and Experimentally Testing the Biosensor

    , M.Sc. Thesis Sharif University of Technology Najmi, Armita (Author) ; Saeedi, Mohammad Saeed (Supervisor) ; Kazemzadeh Hannani, Siamak (Supervisor) ; Shahrokhian, Saeed (Co-Supervisor)
    Diabetic patients, unlike other people whose blood glucose vary in a limited and normal range, encounter hyperglycemia and hypoglycemia, so their glucose level should be measured periodically and kept in the normal range. The aim of this research is to design an implantable integrated microfluidic system in order to regularly measure the glucose level in the human body, using the microdialysis method. The main compartments of this system are a micropump, array of hollow microneedles at the base of them located semipermeable membranes, the channels of dialysis fluid and an electrochemical sensor for measuring the glucose level. The micropump of this system is designed and simulated based on... 

    Design and Fabrication Nanocomposite Modified Electrode Materials Based on Transition Metal Phosphide Using Copper Hydroxide Nanotubes as a Catalytic Substrate for Glucose Sensing in Non-Enzymatic Sensors

    , M.Sc. Thesis Sharif University of Technology Kazemi Abatari, Zeynab (Author) ; Shahrokhian, Saeed (Supervisor)
    In this study, transition metal phosphide, with a high accessible surface and abundant electroactive centers, was used as an electrocatalyst to fabrication an electrochemical sensor of Gloucose. The direct growth of thin film of nanocomposite can be considered as an efficient method to modify the electrode surface, and the application of these modified electrodes as electrochemical sensors. nanocomposite of transition metal phosphide (CuCoP) were directly grown on Cu(OH)2 nanotubes (as-prepared on GCE) in order to design hierarchical core-shell nanostructure with using efficient, inexpensive and fast method. Here, Cu(OH)2 nanotubes not only served as substrate, but also steer the CuCoP to... 

    Design and Computational Evaluation of Sugar-Amino Acid Conjugates as CK2α Inhibitor

    , M.Sc. Thesis Sharif University of Technology Nonanal Nahr, Milad (Author) ; Fattahi, Alireza (Supervisor)
    The aim of this study is to devise innovative compounds that impede the function of CK2α enzyme by incorporating amino acids and sugars into their molecular structure. CK2α, a catalytic subunit of CK2 enzyme, operates autonomously and is the only continuously active kinase that does not require an upstream regulator. Emerging evidence highlights CK2α's crucial role in various cancers and infectious diseases, including Covid-19, indicating that suppressing its function could provide a promising approach to improve patient outcomes. To accomplish this objective, the drug design process must take into account both pharmacokinetic and pharmacodynamic properties. Pharmacokinetics, encompassing...