Sharif Digital Repository

Theanine is a non-protein amino acid which was first isolated from tea plant leaves (Camellia sinensis) and also found in a mushroom named Xerocomus badius and some other Camellia species such as C.japonica and C.sasanqua. Theanine comprises about 50% of amino acids in tea and 1-2% of dry weight of tea leaves. It contributes to the umami taste and unique flavor to tea infusion and has many physiological and pharmaceutical effects such as anti-tumor and anti-cancer activity, neuroprotection, antihypertensive, relaxation, increased focus and anti-obesity effects. So this compound is essential for human body but is not synthesized in it and should be administrated orally. In recent years, study... 

Transglutaminases of family enzymes are implicated in different functions in cell including cellular division and cell adhesion. Several members of this family catalyze formation of isopeptide bond that involved in wound restoration and angiogenesis. Transglutaminase 2 that have been studied in this project, are found in almost every human cell tissue. This enzyme has multiple functions depending on its cell location. In cytoplasm TG2 act as GTPase and is involve in post translational modifications. This enzyme by using calcium form a isopeptide bond between two proteins, isopeptide bond is function in brain cortex and cells creates amyloid structures that including brain diseases, Parkinson...