Loading...
Search for:
gut-on-a-chip
0.046 seconds
Assaying Mucus Adhesion of Oral Drug Delivery Carriers On Gut-on-A-Chip Model
, M.Sc. Thesis Sharif University of Technology ; Taghipoor, Mojtaba (Supervisor) ; Mashayekhan, Shohreh (Supervisor)
Abstract
This study aimed to investigate the penetration of Niosome drug nanocarriers containing curcumin and the effect of PEG surface modification on them in the mucus using a microfluidic chip. The main mucus-forming substance, mucin-type 2, was obtained by extracting from the small intestine of sheep and using calcium ion that regulates the gel properties of the mucus; three different groups, with calcium concentrations of 5, 10, and 15 mM of Calcium were studied as a representative of healthy and Diseased person's mucus. In this research, the study was done on a microfluidic chip; In the processes associated with fabrication of the chip, photolithography, soft lithography, and laser cutting...