Sharif Digital Repository

Morphology and alignment of endothelial cells (ECs) have great influence on plaque formation. These alignments are based on the cyclic strains and wall shear stress (WSS) on the arterial wall. In the present study, cyclic strains and WSS are investigated to predict the secondary plaque locations downstream of the primary stenosis. Therefore, left coronary artery (LCA) with its branches to left anterior descending (LAD) and left circumflex (LCX) are 3D located on a virtual sphere to consider the cardiac motion. Stenoses are placed at the beginning of the bifurcation with varying degrees from 40% to 70% based on diameter reduction. Healthy coronary is also constructed to compare with those of... 

The application of computational fluid dynamics (CFD) has been growing rapidly in biomedical engineering. The altered hemodynamics inside the blood vessels plays a key role in the development of the arterial disease called atherosclerosis, which is the major cause of human death worldwide. Atherosclerosis is often treated with the stenting procedure to restore the normal blood flow. A stent is a tubular, flexible structure, usually made of metals, which is driven and expanded in the blocked arteries. The presence of non-biological device in the artery causes inflammation or re-growth of atherosclerotic lesions in the treated vessels. Several factors including the design of stents and type of... 

In this study, three recent predictors of severity of coronary stenosis including fractional flow reserve (FFR), instantaneous wave free-ratio (iFR) and coronary flow reserve (CFR), are calculated for a number of patient-specific models of left coronary arteries. These patients are admitted to Tehran heart center. The main aim is presenting the optimum numerical and clinical detection technique to assess the severity of coronary stenosis. The effect of geometric features of stenosis is studied on the results of the FFR, iFR, and CFR in order to determine their accuracy. It is observed that CFR does not have a good estimate of the amount of disease. But, iFR, as a less risky test than FFR,... 

Problems with the mitral valve can make the heart less efficient at pumping blood around the body. Severe problems can lead to heart failure if the valve is not surgically repaired or replaced. A simple approximation of the heart geometry is used and the valve dimensions are based on reported measurements. The primary objective for this study is to design and simulate the opening and closing behavior of the mitral valve using 2D fluid-structure interaction (FSI) model using ADINA software in order to evaluate and investigate the hemodynamic performance and problems of mitral valve, in which the blood is described as a viscous incompressible fluid, and the mitral valve is described as an... 

In many neuroscience studies, the aim is to investigate the functional role of a population of neurons in response to a certain stimulus. Electrophysiology methods usually can only record from a small population of neurons and this is not sufficient for studying functional properties of the cortex. An alternative is to use functional neuroimaging methods. However, some of these methods are expensive and also they do not offer suitable spatial and temporal resolutions. Optical imaging systems can solve these problems because they are low-cost, easy to design, and also have good temporal and spatial resolutions. These systems can generate functional maps from the brain. In this study, a...