Sharif Digital Repository

Nowadays, cardiovascular diseases are among the most prevalent cause of death worldwide. Besides, atherosclerosis is a cardiovascular disease happening with the continuous narrowing of vessels, especially medium and large-sized arteries. Moreover, the human aorta is vulnerable to this phenomenon. Atherosclerosis happens when the excess LDL in the blood flow penetrates the arterial wall. Then, the LDL is oxidized, thereby recruiting monocytes as the response against oxidized LDL. After monocytes enter the arterial wall, they differentiate and become macrophages. Macrophages then transform into foam cells by ingesting the oxidized LDL. The fatty foam cells are eventually responsible for the...