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imidazopyridine
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Production of Imidazole Drug Using Metal-Organic Framework UIO-66
, M.Sc. Thesis Sharif University of Technology ; Kazemeini, Mohammad (Supervisor) ; Khorasheh, Farhad (Supervisor) ; Hosseinpour, Vahid (Supervisor)
Abstract
Imidazopyridine, as a pharmaceutical intermediate, finds extensive applications in the pharmaceutical industry, particularly in the production of various antiviral, anticancer, and other bioactive compounds. Currently, the synthesis of this compound is predominantly carried out through batch methods. However, the use of advanced catalysts, such as metal-organic frameworks (MOFs), due to their porous structure and high surface area, offers significant potential for enhancing the efficiency of reactions in medicinal chemistry. In this study, the synthesis of imidazopyridine derivatives was investigated using the UIO-66@Fe2O3 catalyst in a batch system. Various reaction parameters, including...