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in-vitro
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Characterization of Nanohydroxyapatite-Carbon Nanotube on Stainless Steel 316L Produced by Sol-Gel Method
, M.Sc. Thesis Sharif University of Technology ; Nemati, Ali (Supervisor) ; Sadeghian, Zahra (Supervisor)
Abstract
In this investigation, hydroxyapatite-carbon nanotube nano composite coatings were applied on the 316L stainless steel implants. After polishing with 1200 sand paper, stainless steel implants were coated via dip coating method. The specimens were heat treated at 350˚C after being coated with HAP and HAP-CNTs composite. In vitro test was done in simulated body fluid (SBF) in 1 to 4 weeks periods. XRD evaluation of powder obtained from sol-gel process, showed the presence of HAP and CNTs in the powders. Comparison of XRD results of HAP and HAP-CNTs powders showed the better crystalinity of composite hydroxyapatite. After in vitro tests, specimens were studied with atomic force microscope (AFM)...
Experimental Investigation on Growth and Control of Animal Cells Attached on Scaffold
, M.Sc. Thesis Sharif University of Technology ; Vossoughi, Manoochehr (Supervisor) ; Alamzadeh, Iran (Co-Advisor)
Abstract
Major bone defects resulted from diseases or hurts that can not heal naturally, requaire bone transplantation. golden standard for transplantation is autologus one but it has some disad-vantages such as economic burden, the lack of graft source, surgery on patient, and so on. so exploring altrnative ways led to exploit stem cells.traditionally bone marrow mesenchymal stem cells (MSCs) used for stem cell-bsaed bone regeneration. bone marrow aspiration to aquaire stem cells is painfull and give a population of cells such as hematopoetic cells that requaire to seperate and can not be handled in first passages. MSCs can be substituted by multipotent adipose tissue-derived stem cells (ADSCs) in...
Design and Manufacture of Nanostructured Hydroxyapatite coated Foamy core@compact Shell Ti-6Al-4V Nanocomposite
, M.Sc. Thesis Sharif University of Technology ; Sadrnezhad, Khatiboleslam (Supervisor)
Abstract
The main purpose of this research is design and manufacture of nanostructured hydroxyapatite-coated foamy core@compact shell Ti-6Al-4V bone-like composites for utilization as substitutive implant for cortical bone having porous core. The production procedure consist of two steps; (a) fabrication of foamy core@compact shell Ti-6Al-4V alloy using powder metallurgy-space holder technique, (b) precipitation of hydroxyapatite on the Ti-6Al-4V alloy specimens via pulse electrodeposition process. The bone-like structures were designed to reduce the stress shielding which ensures long-term stabilization of implants. It is while that, the hydroxyapatite coating improve the biological response of...