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indoline-2-thion
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Phytochemical and 2DNMR Investigation of Iranian Endemic Plants and Synthesis of Fused Polycyclic Heterocycles
, Ph.D. Dissertation Sharif University of Technology ; Matloubi Moghaddam, Firouz (Supervisor) ; Tafazzoli, Mohsen (Supervisor) ; Amin, Gholamreza (Co-Advisor)
Abstract
Members of Centaurea species are common traditional medicines throughout the world. For this reason medicinal plants are the targets of intense Phytochemical studies. In this research we have investigated Centautea Golestanica which are members of this genus and endemic of Iran. In this research, One Flavonoid, two Sesquiterpenelactones and two triterpenoides were elucidated by advanced spectroscopic techniques such as IR, MS, 1H NMR, 13C NMR and 2D NMR. In continuation of this research, we have reported new and efficient methods for the synthesis of hitherto unknown indole-annulated pentacyclic indolylhydroisoquino lines and naphthooxazocines via tandem dinucleophilic addition of...
The stereoselective synthesis of the tetrahydrothiopyranolr ,Y'-blindole skeletons via tandem reaction of indoline- r-thiones to Baylis-Hillman adduct acetates & Silica-Supported DABCO-tribromide: A New, Versatile and Recyclable Catalyst for the Chemoselective Oxidation of Sulfides to Sulfoxides and Oxidative Coupling of Thiols into Disulfides
,
M.Sc. Thesis
Sharif University of Technology
;
Matloubi Moghaddam, Firouz
(Supervisor)
Abstract
We have reported a new and efficient synthesis of tetrahydrothiopyrano [2,3-b]indole skeletons via unique tandem reaction of indoline-2-thiones to Baylis-Hillman adduct acetates. This protocol is a very mild and simple method for construction heterocycles in a one-step process. This is a convenient and diastereoselective synthesis of methyl 4-aryl-2,3,4,9-tetrahydrothiopyrano[2,3-b]indole-3-carboxylate systems in the presence of K2CO3 in acetonitrile. The major benefits of the current study are the one-pot procedure, high yields and diastereoselectivity, short reaction times and the similarity of the products to the biologically active moieties.
In addition 1, 4-diazabicyclo [2.2.2]...
In addition 1, 4-diazabicyclo [2.2.2]...