Sharif Digital Repository

"osteoarthritis" is one of the most common joint diseases. This disease has a close relationship with factors such as aging, weight gain, genetics, mechanical pressures, and severe injuries. Although the mechanism of this disease is not fully understood, inflammation is one of the main causes of its exacerbation and progression. controlling inflammation can greatly help in controlling the disease. One of the common treatment methods for osteoarthritis is intra-articular injection of hyaluronic acid and triamcinolone as anti-inflammatory drug. Hyaluronic acid is the main component of synovial fluid, with its viscosupplementation property, prevents bones from rubbing against each other in the... 

The objective of this research is to design a drug delivery system that allows anti-inflammatory drugs to be injected directly into the joint (intra-articular injection) for the treatment of arthritis so that reduce the side effects associated with oral consumption of these drugs, increase the duration of drug retention in the joint environment, and reduce the side effects caused by repeated injections while improving effectiveness. To achieve this, first, desirable features were determined by considering the anatomy of the joint environment, the biological changes caused by the disease, and reviewing published articles and commercial products in the field; appropriate drug and raw materials...