Sharif Digital Repository

Due to the importance of hepatitis disease, especially hepatitis C, from public health view point, this research aims to investigate and suggest an efficient medical therapy for this disease. First, available models are analyzed and the suitable one is chosen. Three controllers namely, fixed PI, adaptive PI and exact linearization control (GLC) are designed to control the hepatitis C disease using the drug efficacy as the manipulated variabel. Controller parameters are determined by the Genetic Algorithm (GA) and their performances are evaluated using the selected model. Uncertainties have been considerd in both model structure and parameters and controllers performances are investigated in...