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Fabrication of Solid State Tunable Micro Pores using the Thermoplastic Polymers
, M.Sc. Thesis Sharif University of Technology ; Taghipoor, Mojtaba (Supervisor)
Abstract
The resistive pulse sensing (RPS) method based on the Coulter principle is a powerful method for particle counting and sizing in electrolyte solutions. This method involves measuring a current pulse that is produced as a particle transits a small channel, or pore. Throughout its development the technique has been expanded from detection of biological cells to counting nanoparticles and viruses, and even registering individual molecules, e.g., nucleotides in nucleic acids. This technique combined with microfluidic or nanofluidic systems shows great potential for various bioanalytical applications. An increasing number of production methods have been reported to make apertures, which have been...