Sharif Digital Repository

Several studies based on anti- cancer, anti- metastatic and anti- tumor effects of curcumin have been reported . Besides these benefits, the therapeutic efficacy of curcumin is limited due to its poor aqueous solubility, extensive first-pass metabolism, inadequate tissue absorption and degradation at alkaline pH, which severely diminishes its bioavailability. In this project we seek to solve some of the problems with nanoscience to work more effectively. In the past decade, mesoporous silica nanoparticles (MSNs) have found widespread application as controlled drug delivery systems. Recent reports on the design of capped and gated MSN-based systems have shown promise in preventing premature... 

Theranostic liposomes have recently found a broad range of applications in nanomedicine due to stability, the high solubility of biomacromolecules, bioavailability, efficacy, and low adverse effects. However, the limitations of liposomes concerning the short systemic circulation in the body, limited controllability of the release rate, and the inability of in vivo imaging remain challenging. Herein, the development of novel hybrid ultrasound-activated piezoelectric nanoparticles based on a hybrid liposome nanocarrier composed of poly(vinylidene fluoride‐trifluoroethylene), graphene quantum dots (GQDs), and Silibinin (a hydrophobic drug) is presented. The hybrid nanoparticles are an... 

The tumor is a collection of cells (cell mass) caused by the lack or ineffectiveness of cellular proliferation inhibitors. Many types of cancers are associated with the emergence of a tumor, a tissue with specific physiological characteristics. The tumors grow very fast so researchers try to prevent their growth and eventually destroy them. Thermal ablation by MWA(microwave ablation) is a common and minimally-invasive treatment for primary and secondary liver tumors that can not be cured by surgery. During treatment, the tissue is heated by microwaves and at a temperature higher than 50 degree Celsius, destroyed by thermal ablation. In this study, two thermal models have been used to... 

In recent years, much attention has been paid to the preparation of nanoparticles as carriers for drug delivery. Nanoparticle carriers, by changing the pharmacokinetic properties of the drug, improve the function of the drug and reduce its side effects. In the manufacture of nanoparticles, various materials such as polymers, metal particles, lipids, etc. are used to transfer the drugs, which can produce a different shape and size of the particles depending on their production method. The purpose of this project is the synthesis of liposomal nanoparticles (as nano-carriers) to load an antibiotic (Eucalyptus oil) and study the release of the encapsulated drug in the simulated environment of...