Sharif Digital Repository

This research aims to develop a drug delivery system based on mesoporous silica nanoparticles (MSNPs) for hydrophobic drugs and evaluating their cytotoxicity. The internal environment of the body is aqueous, while most of effective drugs display poor aqueous solubility, resulting in insufficient bioavailability. Due to their several unique properties, such as a large surface area, tunable pore size, facile surface multi functionalization and excellent biocompatibility, MSNPs are recognized as promising and powerful tools to overcome this hurdle. In the present study, MSNPs were synthesized using template removing method and then were functionalized through grafting procedure. They were... 

In recent decades the use of FRP materials for strengthening structures has been developed extensively, thanks to their high strength, sufficient stiffness, high durablity, and ease of use. A great deal of research has been conducted on strengthening reinforced concrete beams and columns with FRP composites. By contrast, not many researches are performed on slabs, especially two-way slabs. In these few researches, the loading and boundary conditions are limited to simplest ones. Therefore, in this thesis, the focus of attention is on strengthening reinforced concrete slabs under various loads and boundary conditions using FRP composites.
In this thesis, first, FRP composites and their...