Designing a Total Knee Replacement to Obtain Minimum Wear on Contact Surfaces and Reduce the Risk of Loosening Using Fgm and Sma

, M.Sc. Thesis Sharif University of Technology Naghibi Beidokhti, Hamid (Author) ; Ahmadiyan, Mohammad Taghi (Supervisor) ; Zohoor, Hassan (Co-Advisor)

Abstract

In recent years, Total Knee Replacement is a highly common surgery. Other than the injuries caused by trauma in accidents among different ages, a need for Total Knee Replacement can arise due to diseases such as Knee Osteoporosis among the elderly which leads to loss of balance in the physiologic properties of knee joint and a failure in load transfer from distal femur to proximal tibia. Currently, the practice of Total Knee Replacement is performed by implanting a mechanical knee between femoral and tibial shafts. Increase in life expectancy of the people with replaced knee, causes the failure of some prostheses due to various factors. Following the failure, a second operation is required...

Bioactive Nanocomposite Coatings Containing Anti-Bacterial Factors with Controlled Release on the Bone Implant

, Ph.D. Dissertation Sharif University of Technology Zarghami, Vahid (Author) ; Ghorbani, Mohammad (Supervisor) ; Shokrgozar, Mohammad Ali (Supervisor) ; Pooshang Bagheri, Kamran (Co-Supervisor)

Abstract

Aseptic loosening and infection are two major problems of bone implants. Aseptic loosening occurs due to poor cell growth and poor adhesion to the implant surface over time. Bone infection at the implant site occurs mainly by the staphylococcus aureus bacteria. In some cases, infection occurs in the short term and in the early times after implantation, and in some cases, infection occurs in later times. The aim of this study is to synthesize and evaluate antibacterial coatings, while having cell growth-promoting components and cell differentiation to solve bone implant problems simultaneously. Also, the issue of bacterial resistance to antibiotics and their risks in bone implants is another...

Design for Fabrication, Fabrication and Calibration of a Knee Prosthesis Laxity and Stability Test Machine

, M.Sc. Thesis Sharif University of Technology Nasiri Khonsari, Hassan (Author) ; Durali, Mohammad (Supervisor)

Abstract

In this project, conceptual and detailed designs of a knee prosthesis constraint testing machine were performed based on ASTM F1223-20 standard. Conceptual and detailed mechanical and electrical design of machine and parts were performed based on common engineering practice and standards. Parts were carefully manufactured and controlled for quality assurance. The machine was then assembled and checked for proof of performance. A plc program was written as machine software. A comprehensive user interface was coded on computer for performing various tests, which can command the machine and view the required data in a graphical environment. Finally, simple experiments were designed and...