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Fabrication and Characterization of PVA/PLA Composites
, M.Sc. Thesis Sharif University of Technology ; Frounchi, Masoud (Supervisor) ; Dadbin, Susan (Supervisor)
Abstract
Poly (vinyl alcohol) (PVA) hydrogel is a biocompatible material, which has been widely applied in drug delivery applications. Microspheres, nanospheres, and other types of particle-based drug delivery vehicles have proven capacity for long-term release. There is growing interest to overcoming the inherent pharmacological limitations of hydrogels by formulating particulate systems into the hydrogel matrix to form new delivery platforms. We here describe a simple composite system based on poly (vinyl alcohol) (PVA) hydrogels containing entrapped drug-loaded poly (lactic acid) (PLA) microspheres for controlled delivery over extended period of time. Gamma-Irradiation and freeze-thawing was...
Study and Synthesis of Biocompatible Polymer and Loading of Peptide Drug for using in Drug Delivery
, M.Sc. Thesis Sharif University of Technology ; Vosoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Co-Advisor)
Abstract
With the rapid development of biotechnology, peptide and protein drugs are now playing an increasingly important role in therapeutics. Compared with chemical drugs, peptide and protein drugs have some limitations such as low stability and rapid deactivation. Biodegradable and biocompatible polymeric micro carriers have been shown to have a high potential for the delivery of peptides and proteins. Among these polymers, alginate has been widely investigated as a biomaterial. Alginates are natural polysaccharide polymers isolated from brown seaweed. Bovine serum albumin (BSA) loaded calcium alginate microspheres produced in this study by a modified w/o emulsification method. The influence of...
Design and Manufacture of a Scaffold with a Drug Delivery System for a Better Tissue Wound Healing Process
, M.Sc. Thesis Sharif University of Technology ; Shamloo, Amir (Supervisor) ; Aryanpour, Masoud (Supervisor)
Abstract
Articular cartilage is devoid of blood vessels, lymphatics, and nerves which gives it a very limited intrinsic healing and repair capabilities. Being under constant harsh biomechanical environment, makes maintaining the health of articular cartilage a vital principle in having healthy joints. Tissue engineering as a method for regeneration of damaged tissue have attracted a lot of attention. Articular cartilage engineered scaffolds act as a macro scale drug delivery system which in addition to having a good mechanical properties similar to that of cartilage tissue, have to provide a highly porous environment for cell migration and proliferation. The aim of this study is to fabricate a drug...