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nanocages
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Protein Nanocages Self-assembly within Membrane Vesicles
, Ph.D. Dissertation Sharif University of Technology ; Ejtehadi, Reza (Supervisor) ; Vossoughi, Manoochehr (Supervisor)
Abstract
To use protein nanocages in pharmaceutical and medical applications, it is necessary to adjust the dose of nanocages inside the membrane vesicles with proper accuracy. Since the packaging of several nanocages inside a vesicle is always associated with a range of sizes, our suggestion is to adjust the system parameters to reach the condition that engulfing occurs for each nanocages and each nanocages is packed inside a vesicle. The interaction energy between a membrane and a protein is one of the important parameters that effectively affects packing efficiency. The effect of this factor on the cooperative behavior of the protein and membrane at the coarse-grain level, as well as their correlated...