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nanogel
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PEG-PLA-Polysccharide Injectable Nanogels for Drug Delivery
, M.Sc. Thesis Sharif University of Technology ; Frounchi, Masoud (Supervisor) ; Dadbin, Sousan (Supervisor)
Abstract
In recent years along with time and cost intensive process of developing new and better drugs for diseases like cancer, scientists and researchers are attempting to develop novel drug delivery systems for already existing drugs.The purpose of these novel drug delivery systems such as nanogels is controlling drug release rate as well as delivery to a specific target tissue in order to reduce side effects. One of the most commonly used drugs for cancer treatment is Doxorubicin HCl, commercially known as Adricin. In this project biodegradable and biocompatible polymers PLA and PEG were used to synthesize nanocarriers for Adricin. These nanocarriers were then dispersed in an agar hydrogel. The...
Synthesis of Smart Nanocomposites from Chitosan, Functionalized with Gold Nanoparticles and Temperature Sensitive Polymers: Investigation of their Application in Light Responsive Nano Vehicles
, M.Sc. Thesis Sharif University of Technology ; Pourjavadi, Ali (Supervisor)
Abstract
With the fast progress of nanotechnology, targeted drug delivery systems have been widely developed due to decreasing in the drug dosage and subsequently side effects of them into body. These smart systems are able to response to the surroundings stimuli. External stimuli in comparison with internal stimuli are more controllable, and can release drug at the targeted side in the desirable times. In the recent studies, there has been an increasing interest in the usage of LASER as an external stimulus due to high precision, short time response, and suitable practical function. For cancer therapy, several studies have been done by focusing on the hyperthermia effects of gold nanoparticles. In...