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    Fabrication and Characterition of Flour Bearing Fibroin/ Nano-TiO2 Biodegradable Nanocomposite for Bone Tissue Engineering

    , Ph.D. Dissertation Sharif University of Technology Johari, Narges (Author) ; Maddah Hosseini, Hamid Reza (Supervisor)
    Abstract
    It is known that Fluoride ions strongly affect bone mineralization and formation. In the present study, the engineered bone tissue scaffolds are fabricated using silk fibroin (SF) and flouridated TiO2 nanoparticles. TiO2 nanoparticles are modified by fluoride ions, and different levels (0, 5, 10, 15 and 20 wt.%) of the fluoridated TiO2 nanoparticles (TiO2-F) were subsequently added to the SF matrix through phase separation method to prepare silk fibroin/flouridated TiO2 nanocomposite scaffolds (SF/TiO2-F). Phase structure, functinal groups, morphology and mechanical properties of the obtained scaffolds were evaluated by X-ray difraction method (XRD), Fourier transform infrared spectroscopy...