Sharif Digital Repository

Nowadays, heterocycle compounds containing sulfur have become very important in various industries, especially the pharmaceutical industry; Therefore, these two projects aim to provide better and more efficient ways to synthesize these types of compounds. In the first project, we developed an efficient one-pot, four-component procedure for the synthesis of 2,6-diamino-4-Aryl-4H-Thiopyran-3,5-dicarbonitrile derivatives via a reaction between primary amines, carbon disulfide, malononitrile, and benzylidenemalononitrile in the presence of magnetic NH2.MIL-101(Fe)/ED as a basic metal-organic framework catalyst. Magnetic NH2.MIL-101(Fe)/ED was synthesized through anchoring FeCl3 on CoFe2O4... 

Nowadays, heterocyclic compounds have become extremely important in various industries, especially the pharmaceutical industry.In this project, an efficient and environmentally friendly path is presented to synthesize numerous rhodanine-oxindole derivatives in polyethylene Glycol in one pot-four components procedure. This pathway doesn't need harsh reaction conditions such as high temperature, long time, catalysts, complicated separation steps, toxic solvents, etc. all products have been made under green strategy with high yield.
 

In the first part of this thesis provided an efficient and easy method for the synthesis of 3-alkylidin-2-oxindoles containing tetrahydropyrazine structure in the absence of catalysts under green conditions. The oxindole unit represents an important structural motif found in natural products and biologically relevant compounds. On the other hand, pyrazines are important and well-known compounds found in nature and many medicinal compounds. According to the aforementioned, it seems that the oxindole compounds containing the pyrazine rings exhibit high biological activity.In the second chapter of this thesis, an efficient study to synthesize thiopyrano [2,3-b] quinoline containing indole... 

A series of innovative and efficient synthetic methods for the preparation of various derivatives of complex organic compounds have been introduced. These methods include one-step, multi-component, catalyzed ring-closing reactions, and kinetically controlled reactions, specifically designed for the synthesis of compounds with unique properties and potential medical applications. In these reactions, compounds such as rodanine-oxindole, dihydrospirocyclopentanebisoxindoles, thioxotiazolidine-indoline-2-ones, oxyindoline-carbamodithioate hybrids, and pyrrolo-pyrazol derivatives with oxindole structures and pharmaceutical potential have been synthesized. One of the prominent features of these...