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Folic Acid Microencapsulation
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor)
Abstract
Most natural folate derivatives are highly sensitive to temperature, oxygen and light and their stability depends on food process condition. Alginate and pectin were evaluated for folic acid encapsulation and increasing its stability. By combining them and optimising encapsulation condition the efficiency was enhanced up to 90% . Furthermore, using polymers in combined form caused decrease in folic acid leakage from capsules in acidic condition of stomach. First of all, the time of encapsulation was measured which was 140-180 minutes. In this study the effect of Calcium Chloride concentration on encapsulation was studied. Therefore, two variables were selected which were pectin to algine...
Co-microencapsulation of Probiotic Bacteria and DHA Fatty Acid; Optimization and Evaluation of the Viability of Probiotic and Oxidative Stability of DHA during Gastrointestinal Tract
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor) ; Vossoughi, Manouchehr (Supervisor)
Abstract
Due to the increased public awareness about the role of food on health, an increased interest of consuming fortified food has grown rapidly. Probiotic bacteria and DHA poly-unsaturated fatty acid are two major bioactive ingredients becoming increasingly popular in food fortification industry due to their beneficial effects. However, high susceptibility of probiotic bacteria during production, maintenance and digestion in acidic and enzymatic conditions of gastrointestinal tract results in decreasing the survivability and therefore reducing health effects in body. Besides, having multiple double bonds in the structure of DHA fatty acid leads to oxidative degradation that produces volatile...
Co-Microencapsulation of Folic Acid and Iron
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor) ; Vossough, Manouchehr (Supervisor)
Abstract
This study aimed to prepare a type of microcapsule that microencapsulates folic acid and iron at the same time and protects these two substances against environmental and gastrointestinal conditions. Simultaneous release of these two nutrients has dual health properties and improves the efficiency of folic acid microencapsulation. In this study, biocomposites were formed containing alginate, pectin, and carboxymethylcellulose, and the microcapsules were synthesized by the ionization of calcium-alginate ions. Biocomposite optimization mixture with 13 experiments using experimental design software, optimal combination design method based on repopulation separator, restoring folic acid...
Synthesis and Characterization of Nanofibrous Polymeric Composite Containing Two-dimensional MXene and Capable of Drug Release for Tissue Engineering Applications
, M.Sc. Thesis Sharif University of Technology ; Simchi, Abdolreza (Supervisor)
Abstract
Nowadays, biocompatible composites are being utilized as scaffolds supporting cell growth promotion and features with the aim of organs regeneration or substitution based on tissue engineering principals. Moreover, in order to improve bioscaffolds features and function, various two-dimensional composite fillers have been under investigation; for instance, Graphene, Boron nitride, Metal dichalcogenides and oxides and black phosphorous and also electrospinning is mentioned as one of the most compatible and conventional processes of scaffold design that is also the main method of fabrication in this study. In addition, it should be pointed that biocompatible polymers and particularly natural...