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Preparation of Nanoparticles Based on Hyperbranched Polyglycerol as Anti Cancer Drug Delivery Systems
, M.Sc. Thesis Sharif University of Technology ; Pourjavadi, Ali (Supervisor) ; Adeli, Mohsen (Co-Advisor)
Abstract
Successful formulation development for poor water soluble drugs is a critical, long-standing and challengeable problem in cancer treatment. One of the methods for transporting low-soluble drugs is using nanoparticles which are able to pass through capillary walls of tumor tissues due to their small size. An example of the nanoparticles is micelle systems. Functionalized β-cyclodextrin (β-CD) by hyper branched polyglycerol (HPG) can dissolve low-soluble compounds. This polymer can be used in preparing micelles. In this project, β-cyclodextrin (β-CD) by anionic reactions is initiator for polymerization of glycidol monomer. Hydrophobic cavity of the β-cyclodextrin (β-CD) in placing the phenyl...
Synthesis and Evaluation of Supramolecular Nanostrutures of Cyclodextrin/Polyglycerol with Controlled Drug Delivery Applications
, Ph.D. Dissertation Sharif University of Technology ; Vossoughi, Manouchehr (Supervisor) ; Adeli, Mohsen (Supervisor) ; Shokrgozar, Mohammad Ali (Supervisor)
Abstract
Today, human is facing and struggling with one of the most deadly disease, Cancer. Accordingly, several research studies are aimed to develop new anticancer drugs. Among the prescribed drugs are Paclitaxel. Unfortunately, despite the anticancer activity, paclitaxel has very low water solubility. To solve this problem several alternatives have been proposed by researchers, e.g. using co-solvents of ethanol:Cremophor El®, as is the case in commercial drug, Taxol®. Unfortunately, these co-solvents have some dangerous and sometimes mortal side effects. To reduce its side effects, researchers have proposed using cyclodextrin as a carrier for paclitaxel on the basis that cyclodextrin has a...