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mRNA-miRNA Interaction Network Analysis on Stages of Colorectal Cancer Abstract
, M.Sc. Thesis Sharif University of Technology ; Roostaazad, Reza (Supervisor) ; Najafi, Ali (Supervisor)
Abstract
Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). An increasing number of studies have shown that mRNAs, miRNAs, can play an important role in various biological processes that are related to cancer. Identifying and determining the relationship between them can help to diagnose and treat cancer.The aim of this study is to identify miRNA and molecular mRNA markers in the stage of polyp formation in order to diagnose colorectal cancer early and also to introduce therapeutic targets in the stage of metastasis.In this study, two microarray data sets GPL15207 and GPL16384 were analyzed to identify different miRNAs and mRNAs from the GEO database in three...