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Design and Fabrication of Peptide-Based Hybrid Hydrogel for Spinal Cord Injury Repair
,
M.Sc. Thesis
Sharif University of Technology
;
Mashayekhan, Shohreh
(Supervisor)
;
Ramezanpour, Soruor
(Supervisor)
Abstract
Spinal cord injury is a systemic disease related to the central nervous system and one of the most severe traumatic diseases that affects a large number of people each year. Inadequate control of the inflammation at the site of injury and the lack of a suitable biomimetic environment are two major and significant factors in the further expansion of the damage. In this research, a polymer/peptide hybrid hydrogel was prepared using a combination of high molecular weight hyaluronic acid and a self-assembling peptide with the IKVAV biological epitope derived from nerve tissue laminin. To create reversible interactions between the polymer and peptide, hyaluronic acid chains were modified with...
Design and Fabrication of Peptide-Based Hybrid Hydrogel for Spinal Cord Injury Repair
,
M.Sc. Thesis
Sharif University of Technology
;
Shojaei, Akbar
(Supervisor)
Abstract
Spinal cord injury is a systemic disease related to the central nervous system and one of the most severe traumatic diseases that affects a large number of people each year. Inadequate control of the inflammation at the site of injury and the lack of a suitable biomimetic environment are two major and significant factors in the further expansion of the damage. In this research, a polymer/peptide hybrid hydrogel was prepared using a combination of high molecular weight hyaluronic acid and a self-assembling peptide with the IKVAV biological epitope derived from nerve tissue laminin. To create reversible interactions between the polymer and peptide, hyaluronic acid chains were modified with...