Sharif Digital Repository

Spinal cord injury is a systemic disease related to the central nervous system and one of the most severe traumatic diseases that affects a large number of people each year. Inadequate control of the inflammation at the site of injury and the lack of a suitable biomimetic environment are two major and significant factors in the further expansion of the damage. In this research, a polymer/peptide hybrid hydrogel was prepared using a combination of high molecular weight hyaluronic acid and a self-assembling peptide with the IKVAV biological epitope derived from nerve tissue laminin. To create reversible interactions between the polymer and peptide, hyaluronic acid chains were modified with...